SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs

Leupyrrins are highly potent antifungal agents. A structure–activity‐relationship study of natural and synthetic derivatives is reported which reveals important insights into the biological relevance of several structural subunits leading to the discovery of highly potent but drastically simplified...

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Autores principales: Wosniok, Paul R., Knopf, Christopher, Dreisigacker, Sandra, Orozco‐Rodriguez, J. Manuel, Hinkelmann, Bettina, Mueller, Peter P., Brönstrup, Mark, Menche, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756798/
https://www.ncbi.nlm.nih.gov/pubmed/32608026
http://dx.doi.org/10.1002/chem.202002622
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author Wosniok, Paul R.
Knopf, Christopher
Dreisigacker, Sandra
Orozco‐Rodriguez, J. Manuel
Hinkelmann, Bettina
Mueller, Peter P.
Brönstrup, Mark
Menche, Dirk
author_facet Wosniok, Paul R.
Knopf, Christopher
Dreisigacker, Sandra
Orozco‐Rodriguez, J. Manuel
Hinkelmann, Bettina
Mueller, Peter P.
Brönstrup, Mark
Menche, Dirk
author_sort Wosniok, Paul R.
collection PubMed
description Leupyrrins are highly potent antifungal agents. A structure–activity‐relationship study of natural and synthetic derivatives is reported which reveals important insights into the biological relevance of several structural subunits leading to the discovery of highly potent but drastically simplified leupylogs that incorporate a stable and readily available aromatic side chain. For their synthesis a concise strategy is described that enables a short and versatile access.
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spelling pubmed-77567982020-12-28 SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs Wosniok, Paul R. Knopf, Christopher Dreisigacker, Sandra Orozco‐Rodriguez, J. Manuel Hinkelmann, Bettina Mueller, Peter P. Brönstrup, Mark Menche, Dirk Chemistry Communications Leupyrrins are highly potent antifungal agents. A structure–activity‐relationship study of natural and synthetic derivatives is reported which reveals important insights into the biological relevance of several structural subunits leading to the discovery of highly potent but drastically simplified leupylogs that incorporate a stable and readily available aromatic side chain. For their synthesis a concise strategy is described that enables a short and versatile access. John Wiley and Sons Inc. 2020-10-15 2020-11-26 /pmc/articles/PMC7756798/ /pubmed/32608026 http://dx.doi.org/10.1002/chem.202002622 Text en © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Wosniok, Paul R.
Knopf, Christopher
Dreisigacker, Sandra
Orozco‐Rodriguez, J. Manuel
Hinkelmann, Bettina
Mueller, Peter P.
Brönstrup, Mark
Menche, Dirk
SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs
title SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs
title_full SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs
title_fullStr SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs
title_full_unstemmed SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs
title_short SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs
title_sort sar studies of the leupyrrins: design and total synthesis of highly potent simplified leupylogs
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756798/
https://www.ncbi.nlm.nih.gov/pubmed/32608026
http://dx.doi.org/10.1002/chem.202002622
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