UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow

A range of 1,3,4‐oxadiazoles have been synthesized using a UV‐B activated flow approach starting from carboxylic acids and 5‐substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and...

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Detalles Bibliográficos
Autores principales: Green, Luke, Livingstone, Keith, Bertrand, Sophie, Peace, Simon, Jamieson, Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756889/
https://www.ncbi.nlm.nih.gov/pubmed/32786060
http://dx.doi.org/10.1002/chem.202002896
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author Green, Luke
Livingstone, Keith
Bertrand, Sophie
Peace, Simon
Jamieson, Craig
author_facet Green, Luke
Livingstone, Keith
Bertrand, Sophie
Peace, Simon
Jamieson, Craig
author_sort Green, Luke
collection PubMed
description A range of 1,3,4‐oxadiazoles have been synthesized using a UV‐B activated flow approach starting from carboxylic acids and 5‐substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.
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spelling pubmed-77568892020-12-28 UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow Green, Luke Livingstone, Keith Bertrand, Sophie Peace, Simon Jamieson, Craig Chemistry Communications A range of 1,3,4‐oxadiazoles have been synthesized using a UV‐B activated flow approach starting from carboxylic acids and 5‐substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids. John Wiley and Sons Inc. 2020-10-12 2020-11-20 /pmc/articles/PMC7756889/ /pubmed/32786060 http://dx.doi.org/10.1002/chem.202002896 Text en © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Green, Luke
Livingstone, Keith
Bertrand, Sophie
Peace, Simon
Jamieson, Craig
UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow
title UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow
title_full UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow
title_fullStr UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow
title_full_unstemmed UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow
title_short UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow
title_sort uv‐induced 1,3,4‐oxadiazole formation from 5‐substituted tetrazoles and carboxylic acids in flow
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756889/
https://www.ncbi.nlm.nih.gov/pubmed/32786060
http://dx.doi.org/10.1002/chem.202002896
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