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Loss of Jag1 cooperates with oncogenic Kras to induce pancreatic cystic neoplasms

Notch signaling exerts both oncogenic and tumor-suppressive functions in the pancreas. In this study, deletion of Jag1 in conjunction with oncogenic Kras(G12D) expression in the mouse pancreas induced rapid development of acinar-to-ductal metaplasia and early stage pancreatic intraepithelial neoplas...

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Detalles Bibliográficos
Autores principales:	Chung, Wen-Cheng, Challagundla, Lavanya, Zhou, Yunyun, Li, Min, Atfi, Azeddine, Xu, Keli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756968/ https://www.ncbi.nlm.nih.gov/pubmed/33268505 http://dx.doi.org/10.26508/lsa.201900503

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