TARGET-Seq: A Protocol for High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing

Single-cell RNA-sequencing technologies are ideally placed to resolve intratumoral heterogeneity. However, the lack of coverage across key mutation hotspots has precluded the correlation of genetic and transcriptional readouts from the same single cell. To overcome this, we developed TARGET-seq, a p...

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Detalles Bibliográficos
Autores principales: Rodriguez-Meira, Alba, O’Sullivan, Jennifer, Rahman, Haseeb, Mead, Adam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757016/
https://www.ncbi.nlm.nih.gov/pubmed/33377019
http://dx.doi.org/10.1016/j.xpro.2020.100125

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