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CircRNA ciRS-7: a Novel Oncogene in Multiple Cancers

circular RNA ciRS-7 (ciRS-7) is a type of endogenous circular RNA (circRNA) with a closed circular structure. Since Hansen first demonstrated that ciRS-7 could serve as a microRNA sponge in 2013, researchers have paid increased attention to this circRNA. ciRS-7 plays a crucial role in regulating RNA...

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Detalles Bibliográficos
Autores principales: Chen, Junwen, Yang, Jun, Fei, Xiang, Wang, Xia, Wang, Kefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757028/
https://www.ncbi.nlm.nih.gov/pubmed/33390857
http://dx.doi.org/10.7150/ijbs.54292
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author Chen, Junwen
Yang, Jun
Fei, Xiang
Wang, Xia
Wang, Kefeng
author_facet Chen, Junwen
Yang, Jun
Fei, Xiang
Wang, Xia
Wang, Kefeng
author_sort Chen, Junwen
collection PubMed
description circular RNA ciRS-7 (ciRS-7) is a type of endogenous circular RNA (circRNA) with a closed circular structure. Since Hansen first demonstrated that ciRS-7 could serve as a microRNA sponge in 2013, researchers have paid increased attention to this circRNA. ciRS-7 plays a crucial role in regulating RNA transcription, downstream gene expression, and protein production. Moreover, ciRS-7 acts as an oncogene and promotes tumor progression through competitively inhibiting miR-7 in various types of cancers. ciRS-7 has been identified to be closely associated with breast cancer, nasopharyngeal carcinoma, lung cancer, hepatocellular carcinoma, cervical cancer, osteosarcoma, melanoma, colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, pancreatic cancer, laryngeal squamous cell carcinoma, and cholangiocarcinoma. In this review, we summarize the biological characteristics, molecular mechanisms, and future challenges of ciRS-7 in multiple tumors.
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spelling pubmed-77570282021-01-01 CircRNA ciRS-7: a Novel Oncogene in Multiple Cancers Chen, Junwen Yang, Jun Fei, Xiang Wang, Xia Wang, Kefeng Int J Biol Sci Review circular RNA ciRS-7 (ciRS-7) is a type of endogenous circular RNA (circRNA) with a closed circular structure. Since Hansen first demonstrated that ciRS-7 could serve as a microRNA sponge in 2013, researchers have paid increased attention to this circRNA. ciRS-7 plays a crucial role in regulating RNA transcription, downstream gene expression, and protein production. Moreover, ciRS-7 acts as an oncogene and promotes tumor progression through competitively inhibiting miR-7 in various types of cancers. ciRS-7 has been identified to be closely associated with breast cancer, nasopharyngeal carcinoma, lung cancer, hepatocellular carcinoma, cervical cancer, osteosarcoma, melanoma, colorectal cancer, esophageal squamous cell carcinoma, gastric cancer, pancreatic cancer, laryngeal squamous cell carcinoma, and cholangiocarcinoma. In this review, we summarize the biological characteristics, molecular mechanisms, and future challenges of ciRS-7 in multiple tumors. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7757028/ /pubmed/33390857 http://dx.doi.org/10.7150/ijbs.54292 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Chen, Junwen
Yang, Jun
Fei, Xiang
Wang, Xia
Wang, Kefeng
CircRNA ciRS-7: a Novel Oncogene in Multiple Cancers
title CircRNA ciRS-7: a Novel Oncogene in Multiple Cancers
title_full CircRNA ciRS-7: a Novel Oncogene in Multiple Cancers
title_fullStr CircRNA ciRS-7: a Novel Oncogene in Multiple Cancers
title_full_unstemmed CircRNA ciRS-7: a Novel Oncogene in Multiple Cancers
title_short CircRNA ciRS-7: a Novel Oncogene in Multiple Cancers
title_sort circrna cirs-7: a novel oncogene in multiple cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757028/
https://www.ncbi.nlm.nih.gov/pubmed/33390857
http://dx.doi.org/10.7150/ijbs.54292
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