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Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study

Objective: Since December 2019, an outbreak of coronavirus disease 2019 (COVID 19) has been experienced from Wuhan, China to the world. A retrospective cohort study was conducted to summarize the clinical characteristics of patients with COVID-19 and to explore the risk factors affecting the disease...

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Autores principales: Lv, Zhengtong, Lv, Shubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757033/
https://www.ncbi.nlm.nih.gov/pubmed/33390828
http://dx.doi.org/10.7150/ijbs.50654
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author Lv, Zhengtong
Lv, Shubin
author_facet Lv, Zhengtong
Lv, Shubin
author_sort Lv, Zhengtong
collection PubMed
description Objective: Since December 2019, an outbreak of coronavirus disease 2019 (COVID 19) has been experienced from Wuhan, China to the world. A retrospective cohort study was conducted to summarize the clinical characteristics of patients with COVID-19 and to explore the risk factors affecting the disease duration in Jiangan Fangcang shelter hospital, Wuhan, China. Methods: Clinical characteristics of 409 patients with COVID-19 were retrospectively analyzed. We describe the clinical characteristics and distribution of discharge time or transfer time for each patient. Then we performed univariate and multivariate Cox regression analysis to identify potential risk factors for progression from non-severe to severe COVID-19 or death. Results: The median disease duration of all patients was 23 days (IQR 19-28). The main symptoms of the patient were fever (95.6%), cough (74.3%), tiredness (21.5%), and so on. Comorbidities mainly included hypertension (30.6%) diabetes (17.6%) and heart disease (12.5%). The univariate Cox regression analysis showed that old age, number of symptoms, the combination of hypertension, heart disease and pulmonary disease were associated with the progression of disease. The multivariate Cox regression analysis showed that old age (HR: 7.294; 95% CI: 1.442-36.888; P = 0.016), the combination of hypertension (HR: 2.230; 95% CI: 1.090-4.562; P = 0.028) and heart disease (HR: 2.650; 95% CI: 1.079-6.510; P = 0.034) were independent risk factors for progression of COVID-19. Conclusions: The age of the patient, the combination of hypertension and heart disease were independent risk factors for the progression of COVID-19. Cautions should be raised for patients with these risk factors.
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spelling pubmed-77570332021-01-01 Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study Lv, Zhengtong Lv, Shubin Int J Biol Sci Research Paper Objective: Since December 2019, an outbreak of coronavirus disease 2019 (COVID 19) has been experienced from Wuhan, China to the world. A retrospective cohort study was conducted to summarize the clinical characteristics of patients with COVID-19 and to explore the risk factors affecting the disease duration in Jiangan Fangcang shelter hospital, Wuhan, China. Methods: Clinical characteristics of 409 patients with COVID-19 were retrospectively analyzed. We describe the clinical characteristics and distribution of discharge time or transfer time for each patient. Then we performed univariate and multivariate Cox regression analysis to identify potential risk factors for progression from non-severe to severe COVID-19 or death. Results: The median disease duration of all patients was 23 days (IQR 19-28). The main symptoms of the patient were fever (95.6%), cough (74.3%), tiredness (21.5%), and so on. Comorbidities mainly included hypertension (30.6%) diabetes (17.6%) and heart disease (12.5%). The univariate Cox regression analysis showed that old age, number of symptoms, the combination of hypertension, heart disease and pulmonary disease were associated with the progression of disease. The multivariate Cox regression analysis showed that old age (HR: 7.294; 95% CI: 1.442-36.888; P = 0.016), the combination of hypertension (HR: 2.230; 95% CI: 1.090-4.562; P = 0.028) and heart disease (HR: 2.650; 95% CI: 1.079-6.510; P = 0.034) were independent risk factors for progression of COVID-19. Conclusions: The age of the patient, the combination of hypertension and heart disease were independent risk factors for the progression of COVID-19. Cautions should be raised for patients with these risk factors. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7757033/ /pubmed/33390828 http://dx.doi.org/10.7150/ijbs.50654 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Lv, Zhengtong
Lv, Shubin
Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study
title Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study
title_full Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study
title_fullStr Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study
title_full_unstemmed Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study
title_short Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study
title_sort clinical characteristics and analysis of risk factors for disease progression of covid-19: a retrospective cohort study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757033/
https://www.ncbi.nlm.nih.gov/pubmed/33390828
http://dx.doi.org/10.7150/ijbs.50654
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