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Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas
Background: To analyze the prevalence proportions and prognostic factors of synchronous distant metastases in patients with tonsil squamous cell carcinomas (TSCC). Methods: TSCC patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database between 2010 and 2014. We exam...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757145/ https://www.ncbi.nlm.nih.gov/pubmed/33390822 http://dx.doi.org/10.7150/ijms.50966 |
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author | Li, Yujiao Hu, Chaosu |
author_facet | Li, Yujiao Hu, Chaosu |
author_sort | Li, Yujiao |
collection | PubMed |
description | Background: To analyze the prevalence proportions and prognostic factors of synchronous distant metastases in patients with tonsil squamous cell carcinomas (TSCC). Methods: TSCC patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database between 2010 and 2014. We examined the association between clinical manifestations and distant metastases using Chi-squared tests. Predictors of 5-year survival were assessed using univariate and multivariate analyses. Results: A total of 6193 patients were analyzed and lung was the most common site of distant metastases. Poorly/undifferentiated differentiation was found to be significantly correlated with lung metastasis (p=0.033) and liver and bone metastases were associated with African American (p=0.000 and p=0.000, respectively). A higher T classification was associated with higher prevalence of lung, liver, bone and brain metastasis (p=0.000, p=0.000, p=0.000 and p=0.007, respectively). The same results were found in N classification in lung, liver, and bone metastasis (p=0.000, p=0.000, and p=0.000, respectively). Worse prognosis was associated with older age, Blacks, lower grade, higher T and N classification, no surgery therapy and more metastatic sites. Conclusion: Lung was the most frequent lesion of synchronous distant metastases and liver and bone metastases were associated with African American. Higher T and N classification were independent prognostic parameters for higher prevalence of lung, bone, liver and brain metastasis. Worse prognosis was associated with older age, African Americans, lower grade, higher T and N classification, no surgery therapy and more metastatic sites. |
format | Online Article Text |
id | pubmed-7757145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-77571452021-01-01 Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas Li, Yujiao Hu, Chaosu Int J Med Sci Research Paper Background: To analyze the prevalence proportions and prognostic factors of synchronous distant metastases in patients with tonsil squamous cell carcinomas (TSCC). Methods: TSCC patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database between 2010 and 2014. We examined the association between clinical manifestations and distant metastases using Chi-squared tests. Predictors of 5-year survival were assessed using univariate and multivariate analyses. Results: A total of 6193 patients were analyzed and lung was the most common site of distant metastases. Poorly/undifferentiated differentiation was found to be significantly correlated with lung metastasis (p=0.033) and liver and bone metastases were associated with African American (p=0.000 and p=0.000, respectively). A higher T classification was associated with higher prevalence of lung, liver, bone and brain metastasis (p=0.000, p=0.000, p=0.000 and p=0.007, respectively). The same results were found in N classification in lung, liver, and bone metastasis (p=0.000, p=0.000, and p=0.000, respectively). Worse prognosis was associated with older age, Blacks, lower grade, higher T and N classification, no surgery therapy and more metastatic sites. Conclusion: Lung was the most frequent lesion of synchronous distant metastases and liver and bone metastases were associated with African American. Higher T and N classification were independent prognostic parameters for higher prevalence of lung, bone, liver and brain metastasis. Worse prognosis was associated with older age, African Americans, lower grade, higher T and N classification, no surgery therapy and more metastatic sites. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7757145/ /pubmed/33390822 http://dx.doi.org/10.7150/ijms.50966 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Li, Yujiao Hu, Chaosu Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas |
title | Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas |
title_full | Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas |
title_fullStr | Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas |
title_full_unstemmed | Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas |
title_short | Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas |
title_sort | prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757145/ https://www.ncbi.nlm.nih.gov/pubmed/33390822 http://dx.doi.org/10.7150/ijms.50966 |
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