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Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments
Somatic cells such as skin fibroblasts, umbilical cord blood, peripheral blood, urinary epithelial cells, etc., are transformed into induced pluripotent stem cells (iPSCs) by reprogramming technology, a milestone in the stem-cell research field. IPSCs are similar to embryonic stem cells (ESCs), exhi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757149/ https://www.ncbi.nlm.nih.gov/pubmed/33390815 http://dx.doi.org/10.7150/ijms.51842 |
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author | Zhang, Xue Li, Zilong Liu, Yi Gai, Zhongtao |
author_facet | Zhang, Xue Li, Zilong Liu, Yi Gai, Zhongtao |
author_sort | Zhang, Xue |
collection | PubMed |
description | Somatic cells such as skin fibroblasts, umbilical cord blood, peripheral blood, urinary epithelial cells, etc., are transformed into induced pluripotent stem cells (iPSCs) by reprogramming technology, a milestone in the stem-cell research field. IPSCs are similar to embryonic stem cells (ESCs), exhibiting the potential to differentiate into various somatic cells. Still, the former avoid problems of immune rejection and medical ethics in the study of ESCs and clinical trials. Neurodevelopmental disorders are chronic developmental brain dysfunctions that affect cognition, exercise, social adaptability, behavior, etc. Due to various inherited or acquired causes, they seriously affect the physical and psychological health of infants and children. These include generalized stunting / mental disability (GDD/ID), Epilepsy, autism spectrum disease (ASD), and attention deficit hyperactivity disorder (ADHD). Most neurodevelopmental disorders are challenging to cure. Establishing a neurodevelopmental disorder system model is essential for researching and treating neurodevelopmental disorders. At this stage, the scarcity of samples is a bigger problem for studying neurological diseases based on the donor, ethics, etc. Some iPSCs are reprogrammed from somatic cells that carry disease-causing mutations. They differentiate into nerve cells by induction, which has the original characteristics of diseases. Disease-specific iPSCs are used to study the mechanism and pathogenesis of neurodevelopmental disorders. The process provided samples and the impetus for developing drugs and developing treatment plans for neurodevelopmental disorders. Here, this article mainly introduced the development of iPSCs, the currently established iPSCs disease models, and artificial organoids related to neurodevelopmental impairments. This technology will promote our understanding of neurodevelopmental impairments and bring great expectations to children with neurological disorders. |
format | Online Article Text |
id | pubmed-7757149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-77571492021-01-01 Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments Zhang, Xue Li, Zilong Liu, Yi Gai, Zhongtao Int J Med Sci Review Somatic cells such as skin fibroblasts, umbilical cord blood, peripheral blood, urinary epithelial cells, etc., are transformed into induced pluripotent stem cells (iPSCs) by reprogramming technology, a milestone in the stem-cell research field. IPSCs are similar to embryonic stem cells (ESCs), exhibiting the potential to differentiate into various somatic cells. Still, the former avoid problems of immune rejection and medical ethics in the study of ESCs and clinical trials. Neurodevelopmental disorders are chronic developmental brain dysfunctions that affect cognition, exercise, social adaptability, behavior, etc. Due to various inherited or acquired causes, they seriously affect the physical and psychological health of infants and children. These include generalized stunting / mental disability (GDD/ID), Epilepsy, autism spectrum disease (ASD), and attention deficit hyperactivity disorder (ADHD). Most neurodevelopmental disorders are challenging to cure. Establishing a neurodevelopmental disorder system model is essential for researching and treating neurodevelopmental disorders. At this stage, the scarcity of samples is a bigger problem for studying neurological diseases based on the donor, ethics, etc. Some iPSCs are reprogrammed from somatic cells that carry disease-causing mutations. They differentiate into nerve cells by induction, which has the original characteristics of diseases. Disease-specific iPSCs are used to study the mechanism and pathogenesis of neurodevelopmental disorders. The process provided samples and the impetus for developing drugs and developing treatment plans for neurodevelopmental disorders. Here, this article mainly introduced the development of iPSCs, the currently established iPSCs disease models, and artificial organoids related to neurodevelopmental impairments. This technology will promote our understanding of neurodevelopmental impairments and bring great expectations to children with neurological disorders. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7757149/ /pubmed/33390815 http://dx.doi.org/10.7150/ijms.51842 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Zhang, Xue Li, Zilong Liu, Yi Gai, Zhongtao Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments |
title | Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments |
title_full | Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments |
title_fullStr | Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments |
title_full_unstemmed | Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments |
title_short | Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments |
title_sort | great expectations: induced pluripotent stem cell technologies in neurodevelopmental impairments |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757149/ https://www.ncbi.nlm.nih.gov/pubmed/33390815 http://dx.doi.org/10.7150/ijms.51842 |
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