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The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis
Acute pancreatitis (AP) is a leading cause of gastrointestinal-related hospital admissions with significant morbidity and mortality. Although the underlying pathophysiology of AP is rather complex, which greatly limits the treatment options, more and more studies have revealed that infiltrating immu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757151/ https://www.ncbi.nlm.nih.gov/pubmed/33390823 http://dx.doi.org/10.7150/ijms.51618 |
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author | Peng, Cheng Li, Zhiqiang Yu, Xiao |
author_facet | Peng, Cheng Li, Zhiqiang Yu, Xiao |
author_sort | Peng, Cheng |
collection | PubMed |
description | Acute pancreatitis (AP) is a leading cause of gastrointestinal-related hospital admissions with significant morbidity and mortality. Although the underlying pathophysiology of AP is rather complex, which greatly limits the treatment options, more and more studies have revealed that infiltrating immune cells play a critical role in the pathogenesis of AP and determine disease severity. Thus, immunomodulatory therapy targeting immune cells and related inflammatory mediators is expected to be a novel treatment modality for AP which may improve the prognosis of patients. Cells of the innate immune system, including macrophages, neutrophils, dendritic cells, and mast cells, represent the majority of infiltrating cells during AP. In this review, an overview of different populations of innate immune cells and their role during AP will be discussed, with a special focus on neutrophils and macrophages. |
format | Online Article Text |
id | pubmed-7757151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-77571512021-01-01 The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis Peng, Cheng Li, Zhiqiang Yu, Xiao Int J Med Sci Review Acute pancreatitis (AP) is a leading cause of gastrointestinal-related hospital admissions with significant morbidity and mortality. Although the underlying pathophysiology of AP is rather complex, which greatly limits the treatment options, more and more studies have revealed that infiltrating immune cells play a critical role in the pathogenesis of AP and determine disease severity. Thus, immunomodulatory therapy targeting immune cells and related inflammatory mediators is expected to be a novel treatment modality for AP which may improve the prognosis of patients. Cells of the innate immune system, including macrophages, neutrophils, dendritic cells, and mast cells, represent the majority of infiltrating cells during AP. In this review, an overview of different populations of innate immune cells and their role during AP will be discussed, with a special focus on neutrophils and macrophages. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7757151/ /pubmed/33390823 http://dx.doi.org/10.7150/ijms.51618 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Peng, Cheng Li, Zhiqiang Yu, Xiao The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis |
title | The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis |
title_full | The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis |
title_fullStr | The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis |
title_full_unstemmed | The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis |
title_short | The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis |
title_sort | role of pancreatic infiltrating innate immune cells in acute pancreatitis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757151/ https://www.ncbi.nlm.nih.gov/pubmed/33390823 http://dx.doi.org/10.7150/ijms.51618 |
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