Cargando…

The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis

Acute pancreatitis (AP) is a leading cause of gastrointestinal-related hospital admissions with significant morbidity and mortality. Although the underlying pathophysiology of AP is rather complex, which greatly limits the treatment options, more and more studies have revealed that infiltrating immu...

Descripción completa

Detalles Bibliográficos
Autores principales: Peng, Cheng, Li, Zhiqiang, Yu, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757151/
https://www.ncbi.nlm.nih.gov/pubmed/33390823
http://dx.doi.org/10.7150/ijms.51618
_version_ 1783626688238714880
author Peng, Cheng
Li, Zhiqiang
Yu, Xiao
author_facet Peng, Cheng
Li, Zhiqiang
Yu, Xiao
author_sort Peng, Cheng
collection PubMed
description Acute pancreatitis (AP) is a leading cause of gastrointestinal-related hospital admissions with significant morbidity and mortality. Although the underlying pathophysiology of AP is rather complex, which greatly limits the treatment options, more and more studies have revealed that infiltrating immune cells play a critical role in the pathogenesis of AP and determine disease severity. Thus, immunomodulatory therapy targeting immune cells and related inflammatory mediators is expected to be a novel treatment modality for AP which may improve the prognosis of patients. Cells of the innate immune system, including macrophages, neutrophils, dendritic cells, and mast cells, represent the majority of infiltrating cells during AP. In this review, an overview of different populations of innate immune cells and their role during AP will be discussed, with a special focus on neutrophils and macrophages.
format Online
Article
Text
id pubmed-7757151
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-77571512021-01-01 The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis Peng, Cheng Li, Zhiqiang Yu, Xiao Int J Med Sci Review Acute pancreatitis (AP) is a leading cause of gastrointestinal-related hospital admissions with significant morbidity and mortality. Although the underlying pathophysiology of AP is rather complex, which greatly limits the treatment options, more and more studies have revealed that infiltrating immune cells play a critical role in the pathogenesis of AP and determine disease severity. Thus, immunomodulatory therapy targeting immune cells and related inflammatory mediators is expected to be a novel treatment modality for AP which may improve the prognosis of patients. Cells of the innate immune system, including macrophages, neutrophils, dendritic cells, and mast cells, represent the majority of infiltrating cells during AP. In this review, an overview of different populations of innate immune cells and their role during AP will be discussed, with a special focus on neutrophils and macrophages. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7757151/ /pubmed/33390823 http://dx.doi.org/10.7150/ijms.51618 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Peng, Cheng
Li, Zhiqiang
Yu, Xiao
The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis
title The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis
title_full The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis
title_fullStr The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis
title_full_unstemmed The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis
title_short The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis
title_sort role of pancreatic infiltrating innate immune cells in acute pancreatitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757151/
https://www.ncbi.nlm.nih.gov/pubmed/33390823
http://dx.doi.org/10.7150/ijms.51618
work_keys_str_mv AT pengcheng theroleofpancreaticinfiltratinginnateimmunecellsinacutepancreatitis
AT lizhiqiang theroleofpancreaticinfiltratinginnateimmunecellsinacutepancreatitis
AT yuxiao theroleofpancreaticinfiltratinginnateimmunecellsinacutepancreatitis
AT pengcheng roleofpancreaticinfiltratinginnateimmunecellsinacutepancreatitis
AT lizhiqiang roleofpancreaticinfiltratinginnateimmunecellsinacutepancreatitis
AT yuxiao roleofpancreaticinfiltratinginnateimmunecellsinacutepancreatitis