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A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota
Not getting enough sleep is a common problem in our society and contributes to numerous health problems, including high blood pressure, diabetes and obesity. Related to these observations, a wealth of studies has underscored the negative impact of both acute and chronic sleep deprivation on cognitiv...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757181/ https://www.ncbi.nlm.nih.gov/pubmed/31515894 http://dx.doi.org/10.1111/jsr.12920 |
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author | El Aidy, Sahar Bolsius, Youri G. Raven, Frank Havekes, Robbert |
author_facet | El Aidy, Sahar Bolsius, Youri G. Raven, Frank Havekes, Robbert |
author_sort | El Aidy, Sahar |
collection | PubMed |
description | Not getting enough sleep is a common problem in our society and contributes to numerous health problems, including high blood pressure, diabetes and obesity. Related to these observations, a wealth of studies has underscored the negative impact of both acute and chronic sleep deprivation on cognitive function. More recently it has become apparent that the gut microbiota composition can be rapidly altered, modulates brain function and is affected by the aforementioned health problems. As such, changes in the microbiota composition may contribute to the behavioural and physiological phenotypes associated with sleep deprivation. It is unclear, however, whether a brief period of sleep deprivation can also negatively impact the gut microbiota. Here, we examined the impact of 5 hr of sleep deprivation on gut microbiota composition of male C57Bl6/J mice. Despite the fact that the overall microbial composition did not change between the control‐ and sleep‐deprived groups, the relative abundance of the Clostridiaceae and Lachnospiraceae were slightly altered in sleep‐deprived animals compared to controls. Together, these data suggest that depriving mice of sleep for 5 hr leads to subtle changes in the gut microbiota composition. |
format | Online Article Text |
id | pubmed-7757181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77571812020-12-28 A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota El Aidy, Sahar Bolsius, Youri G. Raven, Frank Havekes, Robbert J Sleep Res Basic Animal Research Not getting enough sleep is a common problem in our society and contributes to numerous health problems, including high blood pressure, diabetes and obesity. Related to these observations, a wealth of studies has underscored the negative impact of both acute and chronic sleep deprivation on cognitive function. More recently it has become apparent that the gut microbiota composition can be rapidly altered, modulates brain function and is affected by the aforementioned health problems. As such, changes in the microbiota composition may contribute to the behavioural and physiological phenotypes associated with sleep deprivation. It is unclear, however, whether a brief period of sleep deprivation can also negatively impact the gut microbiota. Here, we examined the impact of 5 hr of sleep deprivation on gut microbiota composition of male C57Bl6/J mice. Despite the fact that the overall microbial composition did not change between the control‐ and sleep‐deprived groups, the relative abundance of the Clostridiaceae and Lachnospiraceae were slightly altered in sleep‐deprived animals compared to controls. Together, these data suggest that depriving mice of sleep for 5 hr leads to subtle changes in the gut microbiota composition. John Wiley and Sons Inc. 2019-09-12 2020-12 /pmc/articles/PMC7757181/ /pubmed/31515894 http://dx.doi.org/10.1111/jsr.12920 Text en © 2019 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Basic Animal Research El Aidy, Sahar Bolsius, Youri G. Raven, Frank Havekes, Robbert A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota |
title | A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota |
title_full | A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota |
title_fullStr | A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota |
title_full_unstemmed | A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota |
title_short | A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota |
title_sort | brief period of sleep deprivation leads to subtle changes in mouse gut microbiota |
topic | Basic Animal Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757181/ https://www.ncbi.nlm.nih.gov/pubmed/31515894 http://dx.doi.org/10.1111/jsr.12920 |
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