Novel cholesterol‐dependent regulation of cardiac K(ATP) subunit expression revealed using histone deacetylase inhibitors

We recently discovered that the histone deacetylase inhibitor, trichostatin A (TSA), increases expression of the sulfonylurea receptor 2 (SUR2; Abcc9) subunit of the ATP‐sensitive K(+) (K(ATP)) channel in HL‐1 cardiomyocytes. Interestingly, the increase in SUR2 was abolished with exogenous cholester...

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Detalles Bibliográficos
Autores principales: Geiger, Robert, Fatima, Naheed, Schooley, James F., Smyth, Jeremy T., Haigney, Mark C., Flagg, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757372/
https://www.ncbi.nlm.nih.gov/pubmed/33356020
http://dx.doi.org/10.14814/phy2.14675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757372/
https://www.ncbi.nlm.nih.gov/pubmed/33356020
http://dx.doi.org/10.14814/phy2.14675

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