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The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach

Loss of interstitial cells of Cajal (ICC) has been associated with gastric dysfunction and is also observed during normal aging at ~13% reduction per decade. The impact of ICC loss on gastric slow wave conduction velocity is currently undefined. This study correlated human gastric slow wave velocity...

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Autores principales: Wang, Tim Hsu‐Han, Angeli, Timothy R., Ishida, Shunichi, Du, Peng, Gharibans, Armen, Paskaranandavadivel, Niranchan, Imai, Yohsuke, Miyagawa, Taimei, Abell, Thomas L., Farrugia, Gianrico, Cheng, Leo K., O’Grady, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757374/
https://www.ncbi.nlm.nih.gov/pubmed/33355992
http://dx.doi.org/10.14814/phy2.14659
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author Wang, Tim Hsu‐Han
Angeli, Timothy R.
Ishida, Shunichi
Du, Peng
Gharibans, Armen
Paskaranandavadivel, Niranchan
Imai, Yohsuke
Miyagawa, Taimei
Abell, Thomas L.
Farrugia, Gianrico
Cheng, Leo K.
O’Grady, Gregory
author_facet Wang, Tim Hsu‐Han
Angeli, Timothy R.
Ishida, Shunichi
Du, Peng
Gharibans, Armen
Paskaranandavadivel, Niranchan
Imai, Yohsuke
Miyagawa, Taimei
Abell, Thomas L.
Farrugia, Gianrico
Cheng, Leo K.
O’Grady, Gregory
author_sort Wang, Tim Hsu‐Han
collection PubMed
description Loss of interstitial cells of Cajal (ICC) has been associated with gastric dysfunction and is also observed during normal aging at ~13% reduction per decade. The impact of ICC loss on gastric slow wave conduction velocity is currently undefined. This study correlated human gastric slow wave velocity with ICC loss and aging. High‐resolution gastric slow wave mapping data were screened from a database of 42 patients with severe gastric dysfunction (n = 20) and controls (n = 22). Correlations were performed between corpus slow wave conduction parameters (frequency, velocity, and amplitude) and corpus ICC counts in patients, and with age in controls. Physiological parameters were further integrated into computational models of gastric mixing. Patients: ICC count demonstrated a negative correlation with slow wave velocity in the corpus (i.e., higher velocities with reduced ICC; r (2) = .55; p = .03). ICC count did not correlate with extracellular slow wave amplitude (p = .12) or frequency (p = .84). Aging: Age was positively correlated with slow wave velocity in the corpus (range: 25–74 years; r (2) = .32; p = .02). Age did not correlate with extracellular slow wave amplitude (p = .40) or frequency (p = .34). Computational simulations demonstrated that the gastric emptying rate would increase at higher slow wave velocities. ICC loss and aging are associated with a higher slow wave velocity. The reason for these relationships is unexplained and merit further investigation. Increased slow wave velocity may modulate gastric emptying higher, although in gastroparesis other pathological factors must dominate to prevent emptying.
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spelling pubmed-77573742020-12-23 The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach Wang, Tim Hsu‐Han Angeli, Timothy R. Ishida, Shunichi Du, Peng Gharibans, Armen Paskaranandavadivel, Niranchan Imai, Yohsuke Miyagawa, Taimei Abell, Thomas L. Farrugia, Gianrico Cheng, Leo K. O’Grady, Gregory Physiol Rep Original Research Loss of interstitial cells of Cajal (ICC) has been associated with gastric dysfunction and is also observed during normal aging at ~13% reduction per decade. The impact of ICC loss on gastric slow wave conduction velocity is currently undefined. This study correlated human gastric slow wave velocity with ICC loss and aging. High‐resolution gastric slow wave mapping data were screened from a database of 42 patients with severe gastric dysfunction (n = 20) and controls (n = 22). Correlations were performed between corpus slow wave conduction parameters (frequency, velocity, and amplitude) and corpus ICC counts in patients, and with age in controls. Physiological parameters were further integrated into computational models of gastric mixing. Patients: ICC count demonstrated a negative correlation with slow wave velocity in the corpus (i.e., higher velocities with reduced ICC; r (2) = .55; p = .03). ICC count did not correlate with extracellular slow wave amplitude (p = .12) or frequency (p = .84). Aging: Age was positively correlated with slow wave velocity in the corpus (range: 25–74 years; r (2) = .32; p = .02). Age did not correlate with extracellular slow wave amplitude (p = .40) or frequency (p = .34). Computational simulations demonstrated that the gastric emptying rate would increase at higher slow wave velocities. ICC loss and aging are associated with a higher slow wave velocity. The reason for these relationships is unexplained and merit further investigation. Increased slow wave velocity may modulate gastric emptying higher, although in gastroparesis other pathological factors must dominate to prevent emptying. John Wiley and Sons Inc. 2020-12-23 /pmc/articles/PMC7757374/ /pubmed/33355992 http://dx.doi.org/10.14814/phy2.14659 Text en © 2020 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Wang, Tim Hsu‐Han
Angeli, Timothy R.
Ishida, Shunichi
Du, Peng
Gharibans, Armen
Paskaranandavadivel, Niranchan
Imai, Yohsuke
Miyagawa, Taimei
Abell, Thomas L.
Farrugia, Gianrico
Cheng, Leo K.
O’Grady, Gregory
The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach
title The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach
title_full The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach
title_fullStr The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach
title_full_unstemmed The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach
title_short The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach
title_sort influence of interstitial cells of cajal loss and aging on slow wave conduction velocity in the human stomach
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757374/
https://www.ncbi.nlm.nih.gov/pubmed/33355992
http://dx.doi.org/10.14814/phy2.14659
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