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Blood-based kinase activity profiling: a potential predictor of response to immune checkpoint inhibition in metastatic cancer

BACKGROUND: Many cancer patients do not obtain clinical benefit from immune checkpoint inhibition. Checkpoint blockade targets T cells, suggesting that tyrosine kinase activity profiling of baseline peripheral blood mononuclear cells may predict clinical outcome. METHODS: Here a total of 160 patient...

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Detalles Bibliográficos
Autores principales:	Hurkmans, Daan P, Verdegaal, Els M E, Hogan, Sabrina A, de Wijn, Rik, Hovestad, Lies, van den Heuvel, Dianne M A, Ruijtenbeek, Rob, Welters, Marij J P, van Brakel, Mandy, Basak, Edwin A, Pinedo, Herbert M, Lamers, Cor H J, van de Werken, Harmen J G, Groten, John P, Debets, Reno, Levesque, Mitchell P, Dummer, Reinhard, Kapiteijn, Ellen, Mathijssen, Ron H J, Aerts, Joachim G J V, van der Burg, Sjoerd H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757459/ https://www.ncbi.nlm.nih.gov/pubmed/33427690 http://dx.doi.org/10.1136/jitc-2020-001607

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