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Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods

The ability to alter genomes specifically by CRISPR-Cas gene editing has revolutionized biological research, biotechnology, and medicine. Broad therapeutic application of this technology, however, will require thorough preclinical assessment of off-target editing by homology-based prediction coupled...

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Detalles Bibliográficos
Autores principales:	Chaudhari, Hemangi G., Penterman, Jon, Whitton, Holly J., Spencer, Sarah J., Flanagan, Nicole, Lei Zhang, Maria C., Huang, Elaine, Khedkar, Aditya S., Toomey, J. Mike, Shearer, Courtney A., Needham, Alexander W., Ho, Tony W., Kulman, John D., Cradick, T.J., Kernytsky, Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2020
Materias:	Research Articles: Expanding the CRISPR Toolbox
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757695/ https://www.ncbi.nlm.nih.gov/pubmed/33346710 http://dx.doi.org/10.1089/crispr.2020.0053

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