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Late sodium current and calcium homeostasis in arrhythmogenesis

The cardiac late sodium current (I(Na,late)) is the small sustained component of the sodium current active during the plateau phase of the action potential. Several studies demonstrated that augmentation of the current can lead to cardiac arrhythmias; therefore, I(Na,late) is considered as a promisi...

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Autores principales: Kistamás, Kornél, Hézső, Tamás, Horváth, Balázs, Nánási, Péter P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757849/
https://www.ncbi.nlm.nih.gov/pubmed/33258400
http://dx.doi.org/10.1080/19336950.2020.1854986
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author Kistamás, Kornél
Hézső, Tamás
Horváth, Balázs
Nánási, Péter P
author_facet Kistamás, Kornél
Hézső, Tamás
Horváth, Balázs
Nánási, Péter P
author_sort Kistamás, Kornél
collection PubMed
description The cardiac late sodium current (I(Na,late)) is the small sustained component of the sodium current active during the plateau phase of the action potential. Several studies demonstrated that augmentation of the current can lead to cardiac arrhythmias; therefore, I(Na,late) is considered as a promising antiarrhythmic target. Fundamentally, enlarged I(Na,late) increases Na(+) influx into the cell, which, in turn, is converted to elevated intracellular Ca(2+) concentration through the Na(+)/Ca(2+) exchanger. The excessive Ca(2+) load is known to be proarrhythmic. This review describes the behavior of the voltage-gated Na(+) channels generating I(Na,late) in health and disease and aims to discuss the physiology and pathophysiology of Na(+) and Ca(2+) homeostasis in context with the enhanced I(Na,late) demonstrating also the currently accessible antiarrhythmic choices.
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spelling pubmed-77578492021-01-08 Late sodium current and calcium homeostasis in arrhythmogenesis Kistamás, Kornél Hézső, Tamás Horváth, Balázs Nánási, Péter P Channels (Austin) Review The cardiac late sodium current (I(Na,late)) is the small sustained component of the sodium current active during the plateau phase of the action potential. Several studies demonstrated that augmentation of the current can lead to cardiac arrhythmias; therefore, I(Na,late) is considered as a promising antiarrhythmic target. Fundamentally, enlarged I(Na,late) increases Na(+) influx into the cell, which, in turn, is converted to elevated intracellular Ca(2+) concentration through the Na(+)/Ca(2+) exchanger. The excessive Ca(2+) load is known to be proarrhythmic. This review describes the behavior of the voltage-gated Na(+) channels generating I(Na,late) in health and disease and aims to discuss the physiology and pathophysiology of Na(+) and Ca(2+) homeostasis in context with the enhanced I(Na,late) demonstrating also the currently accessible antiarrhythmic choices. Taylor & Francis 2020-12-21 /pmc/articles/PMC7757849/ /pubmed/33258400 http://dx.doi.org/10.1080/19336950.2020.1854986 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kistamás, Kornél
Hézső, Tamás
Horváth, Balázs
Nánási, Péter P
Late sodium current and calcium homeostasis in arrhythmogenesis
title Late sodium current and calcium homeostasis in arrhythmogenesis
title_full Late sodium current and calcium homeostasis in arrhythmogenesis
title_fullStr Late sodium current and calcium homeostasis in arrhythmogenesis
title_full_unstemmed Late sodium current and calcium homeostasis in arrhythmogenesis
title_short Late sodium current and calcium homeostasis in arrhythmogenesis
title_sort late sodium current and calcium homeostasis in arrhythmogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757849/
https://www.ncbi.nlm.nih.gov/pubmed/33258400
http://dx.doi.org/10.1080/19336950.2020.1854986
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