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On the role of the cellular prion protein in the uptake and signaling of pathological aggregates in neurodegenerative diseases
Neurodegenerative disorders are associated with intra- or extra-cellular deposition of aggregates of misfolded insoluble proteins. These deposits composed of tau, amyloid-β or α-synuclein spread from cell to cell, in a prion-like manner. Novel evidence suggests that the circulating soluble oligomeri...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757855/ https://www.ncbi.nlm.nih.gov/pubmed/33345731 http://dx.doi.org/10.1080/19336896.2020.1854034 |