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Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation
Three rapid spectrophotometric methods were developed for the determination of sunitinib based on the formation of ion-pair complex in acidic medium with bromocresol purple, bromothymol blue, and bromophenol blue. The formed ion-pair complexes, extractable with chloroform, were measured at 422 nm fo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758013/ https://www.ncbi.nlm.nih.gov/pubmed/33680014 http://dx.doi.org/10.22037/ijpr.2020.1101119 |
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author | Souri, Effat Amoon, Eynollah Shabani Ravari, Nazanin Keyghobadi, Fereshteh Barazandeh Tehrani, Maliheh |
author_facet | Souri, Effat Amoon, Eynollah Shabani Ravari, Nazanin Keyghobadi, Fereshteh Barazandeh Tehrani, Maliheh |
author_sort | Souri, Effat |
collection | PubMed |
description | Three rapid spectrophotometric methods were developed for the determination of sunitinib based on the formation of ion-pair complex in acidic medium with bromocresol purple, bromothymol blue, and bromophenol blue. The formed ion-pair complexes, extractable with chloroform, were measured at 422 nm for bromocresol purple, 425 nm for bromothymol blue and 427 nm for bromophenol blue. All these methods were optimized for the pH of buffer and the volume of the reagent. The methods were linear over the range of 1-200 µg/mL for bromocresol purple, 1-150 µg/mL for bromothymol blue, and 2-200 µg/mL for bromophenol blue with a very low limit of quantification and acceptable accuracy and precision. Using the proposed methods for determination of sunitinib in pharmaceutical dosage forms showed reliable results comparable to previously published method. |
format | Online Article Text |
id | pubmed-7758013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-77580132021-03-05 Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation Souri, Effat Amoon, Eynollah Shabani Ravari, Nazanin Keyghobadi, Fereshteh Barazandeh Tehrani, Maliheh Iran J Pharm Res Original Article Three rapid spectrophotometric methods were developed for the determination of sunitinib based on the formation of ion-pair complex in acidic medium with bromocresol purple, bromothymol blue, and bromophenol blue. The formed ion-pair complexes, extractable with chloroform, were measured at 422 nm for bromocresol purple, 425 nm for bromothymol blue and 427 nm for bromophenol blue. All these methods were optimized for the pH of buffer and the volume of the reagent. The methods were linear over the range of 1-200 µg/mL for bromocresol purple, 1-150 µg/mL for bromothymol blue, and 2-200 µg/mL for bromophenol blue with a very low limit of quantification and acceptable accuracy and precision. Using the proposed methods for determination of sunitinib in pharmaceutical dosage forms showed reliable results comparable to previously published method. Shaheed Beheshti University of Medical Sciences 2020 /pmc/articles/PMC7758013/ /pubmed/33680014 http://dx.doi.org/10.22037/ijpr.2020.1101119 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Souri, Effat Amoon, Eynollah Shabani Ravari, Nazanin Keyghobadi, Fereshteh Barazandeh Tehrani, Maliheh Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation |
title | Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation |
title_full | Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation |
title_fullStr | Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation |
title_full_unstemmed | Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation |
title_short | Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation |
title_sort | spectrophotometric methods for determination of sunitinib in pharmaceutical dosage forms based on ion-pair complex formation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758013/ https://www.ncbi.nlm.nih.gov/pubmed/33680014 http://dx.doi.org/10.22037/ijpr.2020.1101119 |
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