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Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation

Three rapid spectrophotometric methods were developed for the determination of sunitinib based on the formation of ion-pair complex in acidic medium with bromocresol purple, bromothymol blue, and bromophenol blue. The formed ion-pair complexes, extractable with chloroform, were measured at 422 nm fo...

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Autores principales: Souri, Effat, Amoon, Eynollah, Shabani Ravari, Nazanin, Keyghobadi, Fereshteh, Barazandeh Tehrani, Maliheh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758013/
https://www.ncbi.nlm.nih.gov/pubmed/33680014
http://dx.doi.org/10.22037/ijpr.2020.1101119
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author Souri, Effat
Amoon, Eynollah
Shabani Ravari, Nazanin
Keyghobadi, Fereshteh
Barazandeh Tehrani, Maliheh
author_facet Souri, Effat
Amoon, Eynollah
Shabani Ravari, Nazanin
Keyghobadi, Fereshteh
Barazandeh Tehrani, Maliheh
author_sort Souri, Effat
collection PubMed
description Three rapid spectrophotometric methods were developed for the determination of sunitinib based on the formation of ion-pair complex in acidic medium with bromocresol purple, bromothymol blue, and bromophenol blue. The formed ion-pair complexes, extractable with chloroform, were measured at 422 nm for bromocresol purple, 425 nm for bromothymol blue and 427 nm for bromophenol blue. All these methods were optimized for the pH of buffer and the volume of the reagent. The methods were linear over the range of 1-200 µg/mL for bromocresol purple, 1-150 µg/mL for bromothymol blue, and 2-200 µg/mL for bromophenol blue with a very low limit of quantification and acceptable accuracy and precision. Using the proposed methods for determination of sunitinib in pharmaceutical dosage forms showed reliable results comparable to previously published method.
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spelling pubmed-77580132021-03-05 Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation Souri, Effat Amoon, Eynollah Shabani Ravari, Nazanin Keyghobadi, Fereshteh Barazandeh Tehrani, Maliheh Iran J Pharm Res Original Article Three rapid spectrophotometric methods were developed for the determination of sunitinib based on the formation of ion-pair complex in acidic medium with bromocresol purple, bromothymol blue, and bromophenol blue. The formed ion-pair complexes, extractable with chloroform, were measured at 422 nm for bromocresol purple, 425 nm for bromothymol blue and 427 nm for bromophenol blue. All these methods were optimized for the pH of buffer and the volume of the reagent. The methods were linear over the range of 1-200 µg/mL for bromocresol purple, 1-150 µg/mL for bromothymol blue, and 2-200 µg/mL for bromophenol blue with a very low limit of quantification and acceptable accuracy and precision. Using the proposed methods for determination of sunitinib in pharmaceutical dosage forms showed reliable results comparable to previously published method. Shaheed Beheshti University of Medical Sciences 2020 /pmc/articles/PMC7758013/ /pubmed/33680014 http://dx.doi.org/10.22037/ijpr.2020.1101119 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Souri, Effat
Amoon, Eynollah
Shabani Ravari, Nazanin
Keyghobadi, Fereshteh
Barazandeh Tehrani, Maliheh
Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation
title Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation
title_full Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation
title_fullStr Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation
title_full_unstemmed Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation
title_short Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-pair Complex Formation
title_sort spectrophotometric methods for determination of sunitinib in pharmaceutical dosage forms based on ion-pair complex formation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758013/
https://www.ncbi.nlm.nih.gov/pubmed/33680014
http://dx.doi.org/10.22037/ijpr.2020.1101119
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