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Measurement of Hansen Solubility Parameters of Human Stratum Corneum
Hansen Solubility Parameters (HSP) of human stratum corneum (SC) represent its polarity and are very important for design and optimization of dermatological formulations. However, there is no directly measured data available in the literature for such a crucial property, which is the subject of the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758015/ https://www.ncbi.nlm.nih.gov/pubmed/33680052 http://dx.doi.org/10.22037/ijpr.2019.112435.13755 |
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author | Ezati, Negin Roberts, Michael Stephen Zhang, Qian Moghimi, Hamid Reza |
author_facet | Ezati, Negin Roberts, Michael Stephen Zhang, Qian Moghimi, Hamid Reza |
author_sort | Ezati, Negin |
collection | PubMed |
description | Hansen Solubility Parameters (HSP) of human stratum corneum (SC) represent its polarity and are very important for design and optimization of dermatological formulations. However, there is no directly measured data available in the literature for such a crucial property, which is the subject of the present investigation. HSP of the SC was measured by solvent uptake here. 18 solvents/mixtures with different HSP values were selected and their uptake by the SC was measured at 32 °C. The solvents were then divided into good and bad solvents according to their uptake into the SC. The HSP discrete parts of “atomic dispersion forces (δD)”, “dipolar intermolecular forces (δP)”, and “hydrogen bonding (δH)” were then calculated using uptake data and HSPiP software. Results showed that δD, δP, and δH values of the SC at 32 °C are 16.5, 12, 7.7 respectively. The obtained HSP values, which were measured for the first time here, were then used to interpret enhancement effects of permeation enhancers and the uptake of vehicles by the SC using Relative Energy Difference (RED), with good correlations. SC HSP values can be further used in transdermal drug delivery, cosmetic formulations, safety issues, etc. |
format | Online Article Text |
id | pubmed-7758015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-77580152021-03-05 Measurement of Hansen Solubility Parameters of Human Stratum Corneum Ezati, Negin Roberts, Michael Stephen Zhang, Qian Moghimi, Hamid Reza Iran J Pharm Res Article Hansen Solubility Parameters (HSP) of human stratum corneum (SC) represent its polarity and are very important for design and optimization of dermatological formulations. However, there is no directly measured data available in the literature for such a crucial property, which is the subject of the present investigation. HSP of the SC was measured by solvent uptake here. 18 solvents/mixtures with different HSP values were selected and their uptake by the SC was measured at 32 °C. The solvents were then divided into good and bad solvents according to their uptake into the SC. The HSP discrete parts of “atomic dispersion forces (δD)”, “dipolar intermolecular forces (δP)”, and “hydrogen bonding (δH)” were then calculated using uptake data and HSPiP software. Results showed that δD, δP, and δH values of the SC at 32 °C are 16.5, 12, 7.7 respectively. The obtained HSP values, which were measured for the first time here, were then used to interpret enhancement effects of permeation enhancers and the uptake of vehicles by the SC using Relative Energy Difference (RED), with good correlations. SC HSP values can be further used in transdermal drug delivery, cosmetic formulations, safety issues, etc. Shaheed Beheshti University of Medical Sciences 2020 /pmc/articles/PMC7758015/ /pubmed/33680052 http://dx.doi.org/10.22037/ijpr.2019.112435.13755 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Ezati, Negin Roberts, Michael Stephen Zhang, Qian Moghimi, Hamid Reza Measurement of Hansen Solubility Parameters of Human Stratum Corneum |
title | Measurement of Hansen Solubility Parameters of Human Stratum Corneum |
title_full | Measurement of Hansen Solubility Parameters of Human Stratum Corneum |
title_fullStr | Measurement of Hansen Solubility Parameters of Human Stratum Corneum |
title_full_unstemmed | Measurement of Hansen Solubility Parameters of Human Stratum Corneum |
title_short | Measurement of Hansen Solubility Parameters of Human Stratum Corneum |
title_sort | measurement of hansen solubility parameters of human stratum corneum |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758015/ https://www.ncbi.nlm.nih.gov/pubmed/33680052 http://dx.doi.org/10.22037/ijpr.2019.112435.13755 |
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