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Measurement of Hansen Solubility Parameters of Human Stratum Corneum

Hansen Solubility Parameters (HSP) of human stratum corneum (SC) represent its polarity and are very important for design and optimization of dermatological formulations. However, there is no directly measured data available in the literature for such a crucial property, which is the subject of the...

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Autores principales: Ezati, Negin, Roberts, Michael Stephen, Zhang, Qian, Moghimi, Hamid Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758015/
https://www.ncbi.nlm.nih.gov/pubmed/33680052
http://dx.doi.org/10.22037/ijpr.2019.112435.13755
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author Ezati, Negin
Roberts, Michael Stephen
Zhang, Qian
Moghimi, Hamid Reza
author_facet Ezati, Negin
Roberts, Michael Stephen
Zhang, Qian
Moghimi, Hamid Reza
author_sort Ezati, Negin
collection PubMed
description Hansen Solubility Parameters (HSP) of human stratum corneum (SC) represent its polarity and are very important for design and optimization of dermatological formulations. However, there is no directly measured data available in the literature for such a crucial property, which is the subject of the present investigation. HSP of the SC was measured by solvent uptake here. 18 solvents/mixtures with different HSP values were selected and their uptake by the SC was measured at 32 °C. The solvents were then divided into good and bad solvents according to their uptake into the SC. The HSP discrete parts of “atomic dispersion forces (δD)”, “dipolar intermolecular forces (δP)”, and “hydrogen bonding (δH)” were then calculated using uptake data and HSPiP software. Results showed that δD, δP, and δH values of the SC at 32 °C are 16.5, 12, 7.7 respectively. The obtained HSP values, which were measured for the first time here, were then used to interpret enhancement effects of permeation enhancers and the uptake of vehicles by the SC using Relative Energy Difference (RED), with good correlations. SC HSP values can be further used in transdermal drug delivery, cosmetic formulations, safety issues, etc.
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spelling pubmed-77580152021-03-05 Measurement of Hansen Solubility Parameters of Human Stratum Corneum Ezati, Negin Roberts, Michael Stephen Zhang, Qian Moghimi, Hamid Reza Iran J Pharm Res Article Hansen Solubility Parameters (HSP) of human stratum corneum (SC) represent its polarity and are very important for design and optimization of dermatological formulations. However, there is no directly measured data available in the literature for such a crucial property, which is the subject of the present investigation. HSP of the SC was measured by solvent uptake here. 18 solvents/mixtures with different HSP values were selected and their uptake by the SC was measured at 32 °C. The solvents were then divided into good and bad solvents according to their uptake into the SC. The HSP discrete parts of “atomic dispersion forces (δD)”, “dipolar intermolecular forces (δP)”, and “hydrogen bonding (δH)” were then calculated using uptake data and HSPiP software. Results showed that δD, δP, and δH values of the SC at 32 °C are 16.5, 12, 7.7 respectively. The obtained HSP values, which were measured for the first time here, were then used to interpret enhancement effects of permeation enhancers and the uptake of vehicles by the SC using Relative Energy Difference (RED), with good correlations. SC HSP values can be further used in transdermal drug delivery, cosmetic formulations, safety issues, etc. Shaheed Beheshti University of Medical Sciences 2020 /pmc/articles/PMC7758015/ /pubmed/33680052 http://dx.doi.org/10.22037/ijpr.2019.112435.13755 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Ezati, Negin
Roberts, Michael Stephen
Zhang, Qian
Moghimi, Hamid Reza
Measurement of Hansen Solubility Parameters of Human Stratum Corneum
title Measurement of Hansen Solubility Parameters of Human Stratum Corneum
title_full Measurement of Hansen Solubility Parameters of Human Stratum Corneum
title_fullStr Measurement of Hansen Solubility Parameters of Human Stratum Corneum
title_full_unstemmed Measurement of Hansen Solubility Parameters of Human Stratum Corneum
title_short Measurement of Hansen Solubility Parameters of Human Stratum Corneum
title_sort measurement of hansen solubility parameters of human stratum corneum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758015/
https://www.ncbi.nlm.nih.gov/pubmed/33680052
http://dx.doi.org/10.22037/ijpr.2019.112435.13755
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