In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of cell cycle progression. Despite its vital role, it has remained challenging to globally map APC/C substrates. By combining orthogonal features of known substrates, we predicted APC/C substrates in si...

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Detalles Bibliográficos
Autores principales: Franks, Jennifer L., Martinez-Chacin, Raquel C., Wang, Xianxi, Tiedemann, Rochelle L., Bonacci, Thomas, Choudhury, Rajarshi, Bolhuis, Derek L., Enrico, Taylor P., Mouery, Ryan D., Damrauer, Jeffrey S., Yan, Feng, Harrison, Joseph S., Major, M. Ben, Hoadley, Katherine A., Suzuki, Aussie, Rothbart, Scott B., Brown, Nicholas G., Emanuele, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758050/
https://www.ncbi.nlm.nih.gov/pubmed/33306668
http://dx.doi.org/10.1371/journal.pbio.3000975

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