TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS

Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesis; however, the mechanisms by which disrupted NCT causes neurodegeneration remain unclear. In a Drosophila screen, we identified ref(2)P/p62, a key regulator of autophagy, as a potent suppressor o...

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Detalles Bibliográficos
Autores principales: Cunningham, Kathleen M, Maulding, Kirstin, Ruan, Kai, Senturk, Mumine, Grima, Jonathan C, Sung, Hyun, Zuo, Zhongyuan, Song, Helen, Gao, Junli, Dubey, Sandeep, Rothstein, Jeffrey D, Zhang, Ke, Bellen, Hugo J, Lloyd, Thomas E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758070/
https://www.ncbi.nlm.nih.gov/pubmed/33300868
http://dx.doi.org/10.7554/eLife.59419

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