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Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery

Postoperative cognitive dysfunction (POCD) is a sever postsurgical neurological complication in the elderly population. As the global acceleration of population ageing, POCD is proved to be a great challenge to the present labor market and healthcare system. In the present study, our findings showed...

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Autores principales: Yan, Jing, Luo, Ailin, Sun, Rao, Tang, Xiaole, Zhao, Yilin, Zhang, Jie, Zhou, Biyun, Zheng, Hua, Yu, Honghui, Li, Shiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758127/
https://www.ncbi.nlm.nih.gov/pubmed/33381265
http://dx.doi.org/10.1155/2020/4635163
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author Yan, Jing
Luo, Ailin
Sun, Rao
Tang, Xiaole
Zhao, Yilin
Zhang, Jie
Zhou, Biyun
Zheng, Hua
Yu, Honghui
Li, Shiyong
author_facet Yan, Jing
Luo, Ailin
Sun, Rao
Tang, Xiaole
Zhao, Yilin
Zhang, Jie
Zhou, Biyun
Zheng, Hua
Yu, Honghui
Li, Shiyong
author_sort Yan, Jing
collection PubMed
description Postoperative cognitive dysfunction (POCD) is a sever postsurgical neurological complication in the elderly population. As the global acceleration of population ageing, POCD is proved to be a great challenge to the present labor market and healthcare system. In the present study, our findings showed that tau acetylation mediated by SIRT1 deficiency resulted in tau hyperphosphorylation in the hippocampus of the aged POCD model and consequently contributed to cognitive impairment. Interestingly, pretreatment with resveratrol almost restored the expression of SIRT1, reduced the levels of acetylated tau and hyperphosphorylated tau in the hippocampus, and improved the cognitive performance in the behavioral tests. What is more, we observed that microglia-derived neuroinflammation resulting from SIRT1 inhibition in microglia probably aggravated the tau acetylation in cultured neurons in vitro. Our findings supported the notion that activation SIRT1 provided dually beneficial effect in the aged POCD model. Taken together, our findings provided the initial evidence that tau acetylation was associated with cognitive impairment in the aged POCD model and paved a promising avenue to prevent POCD by inhibiting tau acetylation in a SIRT1-dependent manner.
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spelling pubmed-77581272020-12-29 Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery Yan, Jing Luo, Ailin Sun, Rao Tang, Xiaole Zhao, Yilin Zhang, Jie Zhou, Biyun Zheng, Hua Yu, Honghui Li, Shiyong Oxid Med Cell Longev Research Article Postoperative cognitive dysfunction (POCD) is a sever postsurgical neurological complication in the elderly population. As the global acceleration of population ageing, POCD is proved to be a great challenge to the present labor market and healthcare system. In the present study, our findings showed that tau acetylation mediated by SIRT1 deficiency resulted in tau hyperphosphorylation in the hippocampus of the aged POCD model and consequently contributed to cognitive impairment. Interestingly, pretreatment with resveratrol almost restored the expression of SIRT1, reduced the levels of acetylated tau and hyperphosphorylated tau in the hippocampus, and improved the cognitive performance in the behavioral tests. What is more, we observed that microglia-derived neuroinflammation resulting from SIRT1 inhibition in microglia probably aggravated the tau acetylation in cultured neurons in vitro. Our findings supported the notion that activation SIRT1 provided dually beneficial effect in the aged POCD model. Taken together, our findings provided the initial evidence that tau acetylation was associated with cognitive impairment in the aged POCD model and paved a promising avenue to prevent POCD by inhibiting tau acetylation in a SIRT1-dependent manner. Hindawi 2020-12-16 /pmc/articles/PMC7758127/ /pubmed/33381265 http://dx.doi.org/10.1155/2020/4635163 Text en Copyright © 2020 Jing Yan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yan, Jing
Luo, Ailin
Sun, Rao
Tang, Xiaole
Zhao, Yilin
Zhang, Jie
Zhou, Biyun
Zheng, Hua
Yu, Honghui
Li, Shiyong
Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery
title Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery
title_full Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery
title_fullStr Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery
title_full_unstemmed Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery
title_short Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery
title_sort resveratrol mitigates hippocampal tau acetylation and cognitive deficit by activation sirt1 in aged rats following anesthesia and surgery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758127/
https://www.ncbi.nlm.nih.gov/pubmed/33381265
http://dx.doi.org/10.1155/2020/4635163
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