Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective

Ocular drug delivery is one of the most challenging issues in ophthalmology because of the complex physiological structure of the eye. Polysaccharide-based nanomaterials have been extensively investigated in recent years as ideal carriers for enhancing the bioavailability of drugs in the ocular syst...

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Detalles Bibliográficos
Autores principales: Yu, Haozhe, Wu, Wenyu, Lin, Xiang, Feng, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758246/
https://www.ncbi.nlm.nih.gov/pubmed/33363130
http://dx.doi.org/10.3389/fbioe.2020.601246
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author Yu, Haozhe
Wu, Wenyu
Lin, Xiang
Feng, Yun
author_facet Yu, Haozhe
Wu, Wenyu
Lin, Xiang
Feng, Yun
author_sort Yu, Haozhe
collection PubMed
description Ocular drug delivery is one of the most challenging issues in ophthalmology because of the complex physiological structure of the eye. Polysaccharide-based nanomaterials have been extensively investigated in recent years as ideal carriers for enhancing the bioavailability of drugs in the ocular system because of their biocompatibility and drug solubilization. From this perspective, we discuss the structural instability of polysaccharides and its impact on the synthesis process; examine the potential for developing bioactive polysaccharide-based ocular drug nanocarriers; propose four strategies for designing novel drug delivery nanomaterials; and suggest reviewing the behavior of nanomaterials in ocular tissues.
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spelling pubmed-77582462020-12-25 Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective Yu, Haozhe Wu, Wenyu Lin, Xiang Feng, Yun Front Bioeng Biotechnol Bioengineering and Biotechnology Ocular drug delivery is one of the most challenging issues in ophthalmology because of the complex physiological structure of the eye. Polysaccharide-based nanomaterials have been extensively investigated in recent years as ideal carriers for enhancing the bioavailability of drugs in the ocular system because of their biocompatibility and drug solubilization. From this perspective, we discuss the structural instability of polysaccharides and its impact on the synthesis process; examine the potential for developing bioactive polysaccharide-based ocular drug nanocarriers; propose four strategies for designing novel drug delivery nanomaterials; and suggest reviewing the behavior of nanomaterials in ocular tissues. Frontiers Media S.A. 2020-12-10 /pmc/articles/PMC7758246/ /pubmed/33363130 http://dx.doi.org/10.3389/fbioe.2020.601246 Text en Copyright © 2020 Yu, Wu, Lin and Feng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Yu, Haozhe
Wu, Wenyu
Lin, Xiang
Feng, Yun
Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective
title Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective
title_full Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective
title_fullStr Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective
title_full_unstemmed Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective
title_short Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective
title_sort polysaccharide-based nanomaterials for ocular drug delivery: a perspective
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758246/
https://www.ncbi.nlm.nih.gov/pubmed/33363130
http://dx.doi.org/10.3389/fbioe.2020.601246
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AT wuwenyu polysaccharidebasednanomaterialsforoculardrugdeliveryaperspective
AT linxiang polysaccharidebasednanomaterialsforoculardrugdeliveryaperspective
AT fengyun polysaccharidebasednanomaterialsforoculardrugdeliveryaperspective

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