Cargando…
Disentangling Biomolecular Corona Interactions With Cell Receptors and Implications for Targeting of Nanomedicines
Nanoparticles are promising tools for nanomedicine in a wide array of therapeutic and diagnostic applications. Yet, despite the advances in the biomedical applications of nanomaterials, relatively few nanomedicines made it to the clinics. The formation of the biomolecular corona on the surface of na...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758247/ https://www.ncbi.nlm.nih.gov/pubmed/33363128 http://dx.doi.org/10.3389/fbioe.2020.599454 |
_version_ | 1783626899281412096 |
---|---|
author | Aliyandi, Aldy Zuhorn, Inge S. Salvati, Anna |
author_facet | Aliyandi, Aldy Zuhorn, Inge S. Salvati, Anna |
author_sort | Aliyandi, Aldy |
collection | PubMed |
description | Nanoparticles are promising tools for nanomedicine in a wide array of therapeutic and diagnostic applications. Yet, despite the advances in the biomedical applications of nanomaterials, relatively few nanomedicines made it to the clinics. The formation of the biomolecular corona on the surface of nanoparticles has been known as one of the challenges toward successful targeting of nanomedicines. This adsorbed protein layer can mask targeting moieties and creates a new biological identity that critically affects the subsequent biological interactions of nanomedicines with cells. Extensive studies have been directed toward understanding the characteristics of this layer of biomolecules and its implications for nanomedicine outcomes at cell and organism levels, yet several aspects are still poorly understood. One aspect that still requires further insights is how the biomolecular corona interacts with and is “read” by the cellular machinery. Within this context, this review is focused on the current understanding of the interactions of the biomolecular corona with cell receptors. First, we address the importance and the role of receptors in the uptake of nanoparticles. Second, we discuss the recent advances and techniques in characterizing and identifying biomolecular corona-receptor interactions. Additionally, we present how we can exploit the knowledge of corona-cell receptor interactions to discover novel receptors for targeting of nanocarriers. Finally, we conclude this review with an outlook on possible future perspectives in the field. A better understanding of the first interactions of nanomaterials with cells, and -in particular -the receptors interacting with the biomolecular corona and involved in nanoparticle uptake, will help for the successful design of nanomedicines for targeted delivery. |
format | Online Article Text |
id | pubmed-7758247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77582472020-12-25 Disentangling Biomolecular Corona Interactions With Cell Receptors and Implications for Targeting of Nanomedicines Aliyandi, Aldy Zuhorn, Inge S. Salvati, Anna Front Bioeng Biotechnol Bioengineering and Biotechnology Nanoparticles are promising tools for nanomedicine in a wide array of therapeutic and diagnostic applications. Yet, despite the advances in the biomedical applications of nanomaterials, relatively few nanomedicines made it to the clinics. The formation of the biomolecular corona on the surface of nanoparticles has been known as one of the challenges toward successful targeting of nanomedicines. This adsorbed protein layer can mask targeting moieties and creates a new biological identity that critically affects the subsequent biological interactions of nanomedicines with cells. Extensive studies have been directed toward understanding the characteristics of this layer of biomolecules and its implications for nanomedicine outcomes at cell and organism levels, yet several aspects are still poorly understood. One aspect that still requires further insights is how the biomolecular corona interacts with and is “read” by the cellular machinery. Within this context, this review is focused on the current understanding of the interactions of the biomolecular corona with cell receptors. First, we address the importance and the role of receptors in the uptake of nanoparticles. Second, we discuss the recent advances and techniques in characterizing and identifying biomolecular corona-receptor interactions. Additionally, we present how we can exploit the knowledge of corona-cell receptor interactions to discover novel receptors for targeting of nanocarriers. Finally, we conclude this review with an outlook on possible future perspectives in the field. A better understanding of the first interactions of nanomaterials with cells, and -in particular -the receptors interacting with the biomolecular corona and involved in nanoparticle uptake, will help for the successful design of nanomedicines for targeted delivery. Frontiers Media S.A. 2020-12-10 /pmc/articles/PMC7758247/ /pubmed/33363128 http://dx.doi.org/10.3389/fbioe.2020.599454 Text en Copyright © 2020 Aliyandi, Zuhorn and Salvati. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Aliyandi, Aldy Zuhorn, Inge S. Salvati, Anna Disentangling Biomolecular Corona Interactions With Cell Receptors and Implications for Targeting of Nanomedicines |
title | Disentangling Biomolecular Corona Interactions With Cell Receptors and Implications for Targeting of Nanomedicines |
title_full | Disentangling Biomolecular Corona Interactions With Cell Receptors and Implications for Targeting of Nanomedicines |
title_fullStr | Disentangling Biomolecular Corona Interactions With Cell Receptors and Implications for Targeting of Nanomedicines |
title_full_unstemmed | Disentangling Biomolecular Corona Interactions With Cell Receptors and Implications for Targeting of Nanomedicines |
title_short | Disentangling Biomolecular Corona Interactions With Cell Receptors and Implications for Targeting of Nanomedicines |
title_sort | disentangling biomolecular corona interactions with cell receptors and implications for targeting of nanomedicines |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758247/ https://www.ncbi.nlm.nih.gov/pubmed/33363128 http://dx.doi.org/10.3389/fbioe.2020.599454 |
work_keys_str_mv | AT aliyandialdy disentanglingbiomolecularcoronainteractionswithcellreceptorsandimplicationsfortargetingofnanomedicines AT zuhorninges disentanglingbiomolecularcoronainteractionswithcellreceptorsandimplicationsfortargetingofnanomedicines AT salvatianna disentanglingbiomolecularcoronainteractionswithcellreceptorsandimplicationsfortargetingofnanomedicines |