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Building Scaffolds for Tubular Tissue Engineering

Hollow organs and tissue systems drive various functions in the body. Many of these hollow or tubular systems, such as vasculature, the intestines, and the trachea, are common targets for tissue engineering, given their relevance to numerous diseases and body functions. As the field of tissue engine...

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Autores principales: Boys, Alexander J., Barron, Sarah L., Tilev, Damyan, Owens, Roisin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758256/
https://www.ncbi.nlm.nih.gov/pubmed/33363127
http://dx.doi.org/10.3389/fbioe.2020.589960
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author Boys, Alexander J.
Barron, Sarah L.
Tilev, Damyan
Owens, Roisin M.
author_facet Boys, Alexander J.
Barron, Sarah L.
Tilev, Damyan
Owens, Roisin M.
author_sort Boys, Alexander J.
collection PubMed
description Hollow organs and tissue systems drive various functions in the body. Many of these hollow or tubular systems, such as vasculature, the intestines, and the trachea, are common targets for tissue engineering, given their relevance to numerous diseases and body functions. As the field of tissue engineering has developed, numerous benchtop models have been produced as platforms for basic science and drug testing. Production of tubular scaffolds for different tissue engineering applications possesses many commonalities, such as the necessity for producing an intact tubular opening and for formation of semi-permeable epithelia or endothelia. As such, the field has converged on a series of manufacturing techniques for producing these structures. In this review, we discuss some of the most common tissue engineered applications within the context of tubular tissues and the methods by which these structures can be produced. We provide an overview of the general structure and anatomy for these tissue systems along with a series of general design criteria for tubular tissue engineering. We categorize methods for manufacturing tubular scaffolds as follows: casting, electrospinning, rolling, 3D printing, and decellularization. We discuss state-of-the-art models within the context of vascular, intestinal, and tracheal tissue engineering. Finally, we conclude with a discussion of the future for these fields.
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spelling pubmed-77582562020-12-25 Building Scaffolds for Tubular Tissue Engineering Boys, Alexander J. Barron, Sarah L. Tilev, Damyan Owens, Roisin M. Front Bioeng Biotechnol Bioengineering and Biotechnology Hollow organs and tissue systems drive various functions in the body. Many of these hollow or tubular systems, such as vasculature, the intestines, and the trachea, are common targets for tissue engineering, given their relevance to numerous diseases and body functions. As the field of tissue engineering has developed, numerous benchtop models have been produced as platforms for basic science and drug testing. Production of tubular scaffolds for different tissue engineering applications possesses many commonalities, such as the necessity for producing an intact tubular opening and for formation of semi-permeable epithelia or endothelia. As such, the field has converged on a series of manufacturing techniques for producing these structures. In this review, we discuss some of the most common tissue engineered applications within the context of tubular tissues and the methods by which these structures can be produced. We provide an overview of the general structure and anatomy for these tissue systems along with a series of general design criteria for tubular tissue engineering. We categorize methods for manufacturing tubular scaffolds as follows: casting, electrospinning, rolling, 3D printing, and decellularization. We discuss state-of-the-art models within the context of vascular, intestinal, and tracheal tissue engineering. Finally, we conclude with a discussion of the future for these fields. Frontiers Media S.A. 2020-12-10 /pmc/articles/PMC7758256/ /pubmed/33363127 http://dx.doi.org/10.3389/fbioe.2020.589960 Text en Copyright © 2020 Boys, Barron, Tilev and Owens. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Boys, Alexander J.
Barron, Sarah L.
Tilev, Damyan
Owens, Roisin M.
Building Scaffolds for Tubular Tissue Engineering
title Building Scaffolds for Tubular Tissue Engineering
title_full Building Scaffolds for Tubular Tissue Engineering
title_fullStr Building Scaffolds for Tubular Tissue Engineering
title_full_unstemmed Building Scaffolds for Tubular Tissue Engineering
title_short Building Scaffolds for Tubular Tissue Engineering
title_sort building scaffolds for tubular tissue engineering
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758256/
https://www.ncbi.nlm.nih.gov/pubmed/33363127
http://dx.doi.org/10.3389/fbioe.2020.589960
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