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Building Scaffolds for Tubular Tissue Engineering
Hollow organs and tissue systems drive various functions in the body. Many of these hollow or tubular systems, such as vasculature, the intestines, and the trachea, are common targets for tissue engineering, given their relevance to numerous diseases and body functions. As the field of tissue engine...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758256/ https://www.ncbi.nlm.nih.gov/pubmed/33363127 http://dx.doi.org/10.3389/fbioe.2020.589960 |
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author | Boys, Alexander J. Barron, Sarah L. Tilev, Damyan Owens, Roisin M. |
author_facet | Boys, Alexander J. Barron, Sarah L. Tilev, Damyan Owens, Roisin M. |
author_sort | Boys, Alexander J. |
collection | PubMed |
description | Hollow organs and tissue systems drive various functions in the body. Many of these hollow or tubular systems, such as vasculature, the intestines, and the trachea, are common targets for tissue engineering, given their relevance to numerous diseases and body functions. As the field of tissue engineering has developed, numerous benchtop models have been produced as platforms for basic science and drug testing. Production of tubular scaffolds for different tissue engineering applications possesses many commonalities, such as the necessity for producing an intact tubular opening and for formation of semi-permeable epithelia or endothelia. As such, the field has converged on a series of manufacturing techniques for producing these structures. In this review, we discuss some of the most common tissue engineered applications within the context of tubular tissues and the methods by which these structures can be produced. We provide an overview of the general structure and anatomy for these tissue systems along with a series of general design criteria for tubular tissue engineering. We categorize methods for manufacturing tubular scaffolds as follows: casting, electrospinning, rolling, 3D printing, and decellularization. We discuss state-of-the-art models within the context of vascular, intestinal, and tracheal tissue engineering. Finally, we conclude with a discussion of the future for these fields. |
format | Online Article Text |
id | pubmed-7758256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77582562020-12-25 Building Scaffolds for Tubular Tissue Engineering Boys, Alexander J. Barron, Sarah L. Tilev, Damyan Owens, Roisin M. Front Bioeng Biotechnol Bioengineering and Biotechnology Hollow organs and tissue systems drive various functions in the body. Many of these hollow or tubular systems, such as vasculature, the intestines, and the trachea, are common targets for tissue engineering, given their relevance to numerous diseases and body functions. As the field of tissue engineering has developed, numerous benchtop models have been produced as platforms for basic science and drug testing. Production of tubular scaffolds for different tissue engineering applications possesses many commonalities, such as the necessity for producing an intact tubular opening and for formation of semi-permeable epithelia or endothelia. As such, the field has converged on a series of manufacturing techniques for producing these structures. In this review, we discuss some of the most common tissue engineered applications within the context of tubular tissues and the methods by which these structures can be produced. We provide an overview of the general structure and anatomy for these tissue systems along with a series of general design criteria for tubular tissue engineering. We categorize methods for manufacturing tubular scaffolds as follows: casting, electrospinning, rolling, 3D printing, and decellularization. We discuss state-of-the-art models within the context of vascular, intestinal, and tracheal tissue engineering. Finally, we conclude with a discussion of the future for these fields. Frontiers Media S.A. 2020-12-10 /pmc/articles/PMC7758256/ /pubmed/33363127 http://dx.doi.org/10.3389/fbioe.2020.589960 Text en Copyright © 2020 Boys, Barron, Tilev and Owens. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Boys, Alexander J. Barron, Sarah L. Tilev, Damyan Owens, Roisin M. Building Scaffolds for Tubular Tissue Engineering |
title | Building Scaffolds for Tubular Tissue Engineering |
title_full | Building Scaffolds for Tubular Tissue Engineering |
title_fullStr | Building Scaffolds for Tubular Tissue Engineering |
title_full_unstemmed | Building Scaffolds for Tubular Tissue Engineering |
title_short | Building Scaffolds for Tubular Tissue Engineering |
title_sort | building scaffolds for tubular tissue engineering |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758256/ https://www.ncbi.nlm.nih.gov/pubmed/33363127 http://dx.doi.org/10.3389/fbioe.2020.589960 |
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