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Schistosomiasis Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a disease of the lung blood vessels that results in right heart failure. PAH is thought to occur in about 5% to 10% of patients with hepatosplenic schistosomiasis, particularly due to S. mansoni. The lung blood vessel injury may result from a combination of e...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758287/ https://www.ncbi.nlm.nih.gov/pubmed/33362796 http://dx.doi.org/10.3389/fimmu.2020.608883 |
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author | Sibomana, Jean Pierre Campeche, Aloma Carvalho-Filho, Roberto J. Correa, Ricardo Amorim Duani, Helena Pacheco Guimaraes, Virginia Hilton, Joan F. Kassa, Biruk Kumar, Rahul Lee, Michael H. Loureiro, Camila M. C. Mazimba, Sula Mickael, Claudia Oliveira, Rudolf K. F. Ota-Arakaki, Jaquelina S. Rezende, Camila Farnese Silva, Luciana C. S. Sinkala, Edford Ahmed, Hanan Yusuf Graham, Brian B. |
author_facet | Sibomana, Jean Pierre Campeche, Aloma Carvalho-Filho, Roberto J. Correa, Ricardo Amorim Duani, Helena Pacheco Guimaraes, Virginia Hilton, Joan F. Kassa, Biruk Kumar, Rahul Lee, Michael H. Loureiro, Camila M. C. Mazimba, Sula Mickael, Claudia Oliveira, Rudolf K. F. Ota-Arakaki, Jaquelina S. Rezende, Camila Farnese Silva, Luciana C. S. Sinkala, Edford Ahmed, Hanan Yusuf Graham, Brian B. |
author_sort | Sibomana, Jean Pierre |
collection | PubMed |
description | Pulmonary arterial hypertension (PAH) is a disease of the lung blood vessels that results in right heart failure. PAH is thought to occur in about 5% to 10% of patients with hepatosplenic schistosomiasis, particularly due to S. mansoni. The lung blood vessel injury may result from a combination of embolization of eggs through portocaval shunts into the lungs causing localized Type 2 inflammatory response and vessel remodeling, triggering of autonomous pathology that becomes independent of the antigen, and high cardiac output as seen in portopulmonary hypertension. The condition is likely underdiagnosed as there is little systematic screening, and risk factors for developing PAH are not known. Screening is done by echocardiography, and formal diagnosis requires invasive right heart catheterization. Patients with Schistosoma-associated PAH show reduced functional capacity and can be treated with pulmonary vasodilators, which improves symptoms and may improve survival. There are animal models of this disease that might help in understanding disease pathogenesis and identify novel targets to screen and treatment. Pathogenic mechanisms include Type 2 immunity and activation and signaling in the TGF-β pathway. There are still major uncertainties regarding Schistosoma-associated PAH development, course and treatment. |
format | Online Article Text |
id | pubmed-7758287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77582872020-12-25 Schistosomiasis Pulmonary Arterial Hypertension Sibomana, Jean Pierre Campeche, Aloma Carvalho-Filho, Roberto J. Correa, Ricardo Amorim Duani, Helena Pacheco Guimaraes, Virginia Hilton, Joan F. Kassa, Biruk Kumar, Rahul Lee, Michael H. Loureiro, Camila M. C. Mazimba, Sula Mickael, Claudia Oliveira, Rudolf K. F. Ota-Arakaki, Jaquelina S. Rezende, Camila Farnese Silva, Luciana C. S. Sinkala, Edford Ahmed, Hanan Yusuf Graham, Brian B. Front Immunol Immunology Pulmonary arterial hypertension (PAH) is a disease of the lung blood vessels that results in right heart failure. PAH is thought to occur in about 5% to 10% of patients with hepatosplenic schistosomiasis, particularly due to S. mansoni. The lung blood vessel injury may result from a combination of embolization of eggs through portocaval shunts into the lungs causing localized Type 2 inflammatory response and vessel remodeling, triggering of autonomous pathology that becomes independent of the antigen, and high cardiac output as seen in portopulmonary hypertension. The condition is likely underdiagnosed as there is little systematic screening, and risk factors for developing PAH are not known. Screening is done by echocardiography, and formal diagnosis requires invasive right heart catheterization. Patients with Schistosoma-associated PAH show reduced functional capacity and can be treated with pulmonary vasodilators, which improves symptoms and may improve survival. There are animal models of this disease that might help in understanding disease pathogenesis and identify novel targets to screen and treatment. Pathogenic mechanisms include Type 2 immunity and activation and signaling in the TGF-β pathway. There are still major uncertainties regarding Schistosoma-associated PAH development, course and treatment. Frontiers Media S.A. 2020-12-10 /pmc/articles/PMC7758287/ /pubmed/33362796 http://dx.doi.org/10.3389/fimmu.2020.608883 Text en Copyright © 2020 Sibomana, Campeche, Carvalho-Filho, Correa, Duani, Pacheco Guimaraes, Hilton, Kassa, Kumar, Lee, Loureiro, Mazimba, Mickael, Oliveira, Ota-Arakaki, Rezende, Silva, Sinkala, Ahmed and Graham http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Sibomana, Jean Pierre Campeche, Aloma Carvalho-Filho, Roberto J. Correa, Ricardo Amorim Duani, Helena Pacheco Guimaraes, Virginia Hilton, Joan F. Kassa, Biruk Kumar, Rahul Lee, Michael H. Loureiro, Camila M. C. Mazimba, Sula Mickael, Claudia Oliveira, Rudolf K. F. Ota-Arakaki, Jaquelina S. Rezende, Camila Farnese Silva, Luciana C. S. Sinkala, Edford Ahmed, Hanan Yusuf Graham, Brian B. Schistosomiasis Pulmonary Arterial Hypertension |
title | Schistosomiasis Pulmonary Arterial Hypertension |
title_full | Schistosomiasis Pulmonary Arterial Hypertension |
title_fullStr | Schistosomiasis Pulmonary Arterial Hypertension |
title_full_unstemmed | Schistosomiasis Pulmonary Arterial Hypertension |
title_short | Schistosomiasis Pulmonary Arterial Hypertension |
title_sort | schistosomiasis pulmonary arterial hypertension |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758287/ https://www.ncbi.nlm.nih.gov/pubmed/33362796 http://dx.doi.org/10.3389/fimmu.2020.608883 |
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