FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration

BACKGROUND: Intervertebral disk (IVD) degeneration is the most common cause of lower back pain. Inhibiting inflammation is a key strategy for delaying IVD degeneration. Tacrolimus (FK506) is a potent immunosuppressive agent that is also beneficial to chondrocytes via alleviating inflammation. Howeve...

Descripción completa

Detalles Bibliográficos
Autores principales: Ge, Jun, Wang, Yingjie, Yan, Qi, Wu, Cenhao, Yu, Hao, Yang, Huilin, Zou, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758291/
https://www.ncbi.nlm.nih.gov/pubmed/33363168
http://dx.doi.org/10.3389/fcell.2020.608308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758291/
https://www.ncbi.nlm.nih.gov/pubmed/33363168
http://dx.doi.org/10.3389/fcell.2020.608308

Ejemplares similares