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FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration

BACKGROUND: Intervertebral disk (IVD) degeneration is the most common cause of lower back pain. Inhibiting inflammation is a key strategy for delaying IVD degeneration. Tacrolimus (FK506) is a potent immunosuppressive agent that is also beneficial to chondrocytes via alleviating inflammation. Howeve...

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Detalles Bibliográficos
Autores principales:	Ge, Jun, Wang, Yingjie, Yan, Qi, Wu, Cenhao, Yu, Hao, Yang, Huilin, Zou, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758291/ https://www.ncbi.nlm.nih.gov/pubmed/33363168 http://dx.doi.org/10.3389/fcell.2020.608308

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