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A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1

Cas13a, an effector of type VI CRISPR-Cas systems, is an RNA guided RNase with multiplexing and therapeutic potential. This study employs the Leptotrichia shahii (Lsh) Cas13a and a repeat-based CRISPR RNA (crRNA) to track and eliminate toxic RNA aggregates in myotonic dystrophy type 1 (DM1) – a neur...

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Detalles Bibliográficos
Autores principales:	Zhang, Nan, Bewick, Brittani, Xia, Guangbin, Furling, Denis, Ashizawa, Tetsuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758406/ https://www.ncbi.nlm.nih.gov/pubmed/33362853 http://dx.doi.org/10.3389/fgene.2020.594576

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