Preclinical and first-in-human-brain-cancer applications of [(18)F]poly (ADP-ribose) polymerase inhibitor PET/MR

BACKGROUND: We report preclinical and first-in-human-brain-cancer data using a targeted poly (ADP-ribose) polymerase 1 (PARP1) binding PET tracer, [(18)F]PARPi, as a diagnostic tool to differentiate between brain cancers and treatment-related changes. METHODS: We applied a glioma model in p53-defici...

Descripción completa

Detalles Bibliográficos
Autores principales: Young, Robert J, Demétrio De Souza França, Paula, Pirovano, Giacomo, Piotrowski, Anna F, Nicklin, Philip J, Riedl, Christopher C, Schwartz, Jazmin, Bale, Tejus A, Donabedian, Patrick L, Kossatz, Susanne, Burnazi, Eva M, Roberts, Sheryl, Lyashchenko, Serge K, Miller, Alexandra M, Moss, Nelson S, Fiasconaro, Megan, Zhang, Zhigang, Mauguen, Audrey, Reiner, Thomas, Dunphy, Mark P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Clinical Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758909/
https://www.ncbi.nlm.nih.gov/pubmed/33392502
http://dx.doi.org/10.1093/noajnl/vdaa119

Ejemplares similares

Ejemplares similares