Cargando…

Exploration the Mechanism of Doxorubicin-Induced Heart Failure in Rats by Integration of Proteomics and Metabolomics Data

Heart failure is a common systemic disease with high morbidity and mortality worldwide. Doxorubicin (DOX) is a commonly used anthracycline broad-spectrum antitumor antibiotic with strong antitumor effect and definite curative effect. However, cardiotoxicity is the adverse reaction of drug dose cumul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Yu, Fan, Simiao, Shu, Lexin, Huang, Wei, Xie, Lijuan, Bi, Chenghao, Yu, Hongxin, Wang, Yuming, Li, Yubo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758990/ https://www.ncbi.nlm.nih.gov/pubmed/33362553 http://dx.doi.org/10.3389/fphar.2020.600561

Ejemplares similares

Integrating Metabolomics and Network Pharmacology to Explore the Mechanism of Tongmai Yangxin Pills in Ameliorating Doxorubicin-Induced Cardiotoxicity
por: Shu, Lexin, et al.
Publicado: (2023)

A New Strategy for the Rapid Identification and Validation of the Direct Targets of Aconitine-Induced Cardiotoxicity
por: Wei, Jinxia, et al.
Publicado: (2021)

Pharmacological effects and mechanisms of YiYiFuZi powder in chronic heart disease revealed by metabolomics and network pharmacology
por: Wang, Yuming, et al.
Publicado: (2023)

Exploring the mechanism of anti-chronic heart failure effect of qiweiqiangxin І granules based on metabolomics
por: Zhong, Wanru, et al.
Publicado: (2023)

Integrated Network Pharmacology and Metabolomics Analysis of the Therapeutic Effects of Zi Dian Fang on Immune Thrombocytopenic Purpura
por: Li, Yubo, et al.
Publicado: (2018)

Phosphoproteomic and proteomic profiling in post-infarction chronic heart failure
por: Wang, Jiayue, et al.
Publicado: (2023)

Mesaconine alleviates doxorubicin-triggered cardiotoxicity and heart failure by activating PINK1-dependent cardiac mitophagy
por: Zhou, Ji-Chao, et al.
Publicado: (2023)

Integrated Proteomics and Metabolomics Link Acne to the Action Mechanisms of Cryptotanshinone Intervention
por: Zhu, Zhaoming, et al.
Publicado: (2021)

The mechanism of Renshen-Fuzi herb pair for treating heart failure—Integrating a cardiovascular pharmacological assessment with serum metabolomics
por: Chen, Xiaofei, et al.
Publicado: (2022)

Integrated Plasma and Bile Metabolomics Based on an UHPLC-Q/TOF-MS and Network Pharmacology Approach to Explore the Potential Mechanism of Schisandra chinensis-Protection From Acute Alcoholic Liver Injury
por: Su, Lianlin, et al.
Publicado: (2020)

Integrative Metabolomics, Proteomics and Transcriptomics Analysis Reveals Liver Toxicity of Mesoporous Silica Nanoparticles
por: Li, Jing, et al.
Publicado: (2022)

Integration of proteomic and metabolomic characterization in atrial fibrillation-induced heart failure
por: Zhang, Haiyu, et al.
Publicado: (2022)

Integrating Metabolomics and Network Analysis for Exploring the Mechanism Underlying the Antidepressant Activity of Paeoniflorin in Rats With CUMS-Induced Depression
por: Lei, Chaofang, et al.
Publicado: (2022)

Trimetazidine in Heart Failure
por: Shu, Hongyang, et al.
Publicado: (2021)

Salsolinol Attenuates Doxorubicin-Induced Chronic Heart Failure in Rats and Improves Mitochondrial Function in H9c2 Cardiomyocytes
por: Wen, Jianxia, et al.
Publicado: (2019)

Biomarkers of PEGylated Liposomal Doxorubicin-Induced Hypersensitivity Reaction in Breast Cancer Patients Based on Metabolomics
por: Zhuang, Wei, et al.
Publicado: (2022)

Integrated Fecal Microbiome and Serum Metabolomics Analysis Reveals Abnormal Changes in Rats with Immunoglobulin A Nephropathy and the Intervention Effect of Zhen Wu Tang
por: Li, Jicheng, et al.
Publicado: (2021)

Yang-xin-xue keli exerts therapeutic effects via regulating mitochondrial homeostasis and function in doxorubicin-induced rat heart failure
por: Long, Kunlan, et al.
Publicado: (2022)

Identification of key pharmacodynamic markers of American ginseng against heart failure based on metabolomics and zebrafish model
por: Dong, Rong, et al.
Publicado: (2022)

Anxiolytic effect of YangshenDingzhi granules: Integrated network pharmacology and hippocampal metabolomics
por: Lv, Shimeng, et al.
Publicado: (2022)

Revealing the mechanism of raw and vinegar-processed Curcuma aromatica Salisb. [Zingiberaceae] regulates primary dysmenorrhea in rats via integrated metabolomics
por: Su, Lianlin, et al.
Publicado: (2022)

Exploring the Use of Pegylated Liposomal Doxorubicin (Caelyx(®)) as Pressurized Intraperitoneal Aerosol Chemotherapy
por: Robella, Manuela, et al.
Publicado: (2019)

Toxicokinetics of Arenobufagin and its Cardiotoxicity Mechanism Exploration Based on Lipidomics and Proteomics Approaches in Rats
por: Zhao, Lijuan, et al.
Publicado: (2021)

UHPLC Q-Exactive MS-Based Serum Metabolomics to Explore the Effect Mechanisms of Immunological Activity of Astragalus Polysaccharides With Different Molecular Weights
por: Li, Ke, et al.
Publicado: (2020)

Therapeutic mechanism of Curcuma aromatica Salisb. rhizome against coronary heart disease based on integrated network pharmacology, pharmacological evaluation and lipidomics
por: Fei, Chenghao, et al.
Publicado: (2022)

Integrative proteomics and metabolomics approach to identify the key roles of icariin-mediated protective effects against cyclophosphamide-induced spermatogenesis dysfunction in mice
por: Fang, Chunyan, et al.
Publicado: (2022)

Integrating metabolomics, bionics, and culturomics to study probiotics-driven drug metabolism
por: Li, Bohai, et al.
Publicado: (2023)

Integrating Pharmacokinetics Study, Network Analysis, and Experimental Validation to Uncover the Mechanism of Qiliqiangxin Capsule Against Chronic Heart Failure
por: Zhang, Yu, et al.
Publicado: (2019)

Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology
por: Li, Shanze, et al.
Publicado: (2021)

Discovery of Novel Doxorubicin Metabolites in MCF7 Doxorubicin-Resistant Cells
por: Wang, Xu, et al.
Publicado: (2019)

Proteomic Analysis Reveals the Protective Effects of Yiqi Fumai Lyophilized Injection on Chronic Heart Failure by Improving Myocardial Energy Metabolism
por: Han, Xiaoying, et al.
Publicado: (2021)

Huoxue Qingre decoction used for treatment of coronary heart disease network analysis and metabolomic evaluation
por: Tan, Yu-Qing, et al.
Publicado: (2022)

Cost effectiveness analyses of pharmacological treatments in heart failure
por: Lim, Audrey Huili, et al.
Publicado: (2022)

Corrigendum: Discovery of Novel Doxorubicin Metabolites in MCF7 Doxorubicin-Resistant Cells
por: Wang, Xu, et al.
Publicado: (2020)

Exploring a four-gene risk model based on doxorubicin resistance-associated lncRNAs in hepatocellular carcinoma
por: Zhang, Zunyi, et al.
Publicado: (2022)

Metabolomics and Integrative Omics for the Development of Thai Traditional Medicine
por: Khoomrung, Sakda, et al.
Publicado: (2017)

Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia
por: Pang, Han-Qing, et al.
Publicado: (2018)

Light-Responsive Micelles Loaded With Doxorubicin for Osteosarcoma Suppression
por: Chen, Jiayi, et al.
Publicado: (2021)

aFGF Targeted Mediated by Novel Nanoparticles-Microbubble Complex Combined With Ultrasound-Targeted Microbubble Destruction attenuates Doxorubicin-Induced Heart Failure via Anti-Apoptosis and Promoting Cardiac Angiogenesis
por: Zhou, Nan-Qian, et al.
Publicado: (2021)

Combined metabolomics and proteomics to reveal beneficial mechanisms of Dendrobium fimbriatum against gastric mucosal injury
por: Sun, Jing, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_e2n43megc0126pnur0vag603ap