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Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review

The aim of the present review is to summarize the prevalence of abnormal levels of various metal micronutrients including copper (Cu), iron (Fe), magnesium (Mg), zinc (Zn), and selenium (Se) in Autism Spectrum Disorder (ASD) using hair, nail and serum samples. A correlation of selected abnormal meta...

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Detalles Bibliográficos
Autores principales: Behl, Supriya, Mehta, Sunil, Pandey, Mukesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759187/
https://www.ncbi.nlm.nih.gov/pubmed/33362464
http://dx.doi.org/10.3389/fnmol.2020.586209
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author Behl, Supriya
Mehta, Sunil
Pandey, Mukesh K.
author_facet Behl, Supriya
Mehta, Sunil
Pandey, Mukesh K.
author_sort Behl, Supriya
collection PubMed
description The aim of the present review is to summarize the prevalence of abnormal levels of various metal micronutrients including copper (Cu), iron (Fe), magnesium (Mg), zinc (Zn), and selenium (Se) in Autism Spectrum Disorder (ASD) using hair, nail and serum samples. A correlation of selected abnormal metal ions with known neurodevelopmental processes using Gene Ontology (GO) term was also conducted. Data included in this review are derived from ASD clinical studies performed globally. Metal ion disparity data is also analyzed and discussed based on gender (Male/Female) to establish any gender dependent correlation. Finally, a rational perspective and possible path to better understand the role of metal micronutrients in ASD is suggested.
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spelling pubmed-77591872020-12-25 Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review Behl, Supriya Mehta, Sunil Pandey, Mukesh K. Front Mol Neurosci Neuroscience The aim of the present review is to summarize the prevalence of abnormal levels of various metal micronutrients including copper (Cu), iron (Fe), magnesium (Mg), zinc (Zn), and selenium (Se) in Autism Spectrum Disorder (ASD) using hair, nail and serum samples. A correlation of selected abnormal metal ions with known neurodevelopmental processes using Gene Ontology (GO) term was also conducted. Data included in this review are derived from ASD clinical studies performed globally. Metal ion disparity data is also analyzed and discussed based on gender (Male/Female) to establish any gender dependent correlation. Finally, a rational perspective and possible path to better understand the role of metal micronutrients in ASD is suggested. Frontiers Media S.A. 2020-12-10 /pmc/articles/PMC7759187/ /pubmed/33362464 http://dx.doi.org/10.3389/fnmol.2020.586209 Text en Copyright © 2020 Behl, Mehta and Pandey. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Behl, Supriya
Mehta, Sunil
Pandey, Mukesh K.
Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review
title Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review
title_full Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review
title_fullStr Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review
title_full_unstemmed Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review
title_short Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review
title_sort abnormal levels of metal micronutrients and autism spectrum disorder: a perspective review
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759187/
https://www.ncbi.nlm.nih.gov/pubmed/33362464
http://dx.doi.org/10.3389/fnmol.2020.586209
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