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Regulating Intestinal Microbiota in the Prevention and Treatment of Alcohol-Related Liver Disease

When alcohol-related liver disease occurs, the number and composition ratio of intestinal microorganisms will accordingly change. The alcohol-induced changes in the intestinal microbiota play a pivotal role in the process of developing the alcohol-related liver disease through the translocation of m...

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Autores principales: Chi, Xin, Pan, Calvin Q., Liu, Shunai, Cheng, Danying, Cao, Ziwen, Xing, Huichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759392/
https://www.ncbi.nlm.nih.gov/pubmed/33381475
http://dx.doi.org/10.1155/2020/6629196
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author Chi, Xin
Pan, Calvin Q.
Liu, Shunai
Cheng, Danying
Cao, Ziwen
Xing, Huichun
author_facet Chi, Xin
Pan, Calvin Q.
Liu, Shunai
Cheng, Danying
Cao, Ziwen
Xing, Huichun
author_sort Chi, Xin
collection PubMed
description When alcohol-related liver disease occurs, the number and composition ratio of intestinal microorganisms will accordingly change. The alcohol-induced changes in the intestinal microbiota play a pivotal role in the process of developing the alcohol-related liver disease through the translocation of microbial products due to increased intestinal permeability. In recent years, therapeutic interventions with a concentration on regulating intestinal microbiota have been conducted for patients with alcohol-related liver disease. We aimed to provide a critical review and updates on the prevention and treatment of alcohol-related liver disease through regulating intestinal microbiota. A literature search was performed on the PubMed database for studies published in English about the therapeutic intervention with microbiota using animal models and patients with alcohol-related liver disease (1/2010–4/2020). The accumulating pieces of evidence suggest that the therapeutic use of probiotics, prebiotics, antibiotics, phages, or fecal microbial transplantation may have several influences on alcohol-related liver disease patients. Emergent data unveiled that these interventions can further regulate the composition of intestinal microbiota, minimize the negative impact of microbiota on the liver, and prevent disease progression from mild to severe alcoholic hepatitis, fibrosis, cirrhosis, or even liver cancer. The current review provides updates on the advances of therapeutic interventions with the effects of regulating intestinal microbiota on patients who have alcohol-related liver disease. In addition, the data gaps and research directions on further exploration of the role of intestinal microbiota for the management of the alcohol-related liver disease are also discussed.
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spelling pubmed-77593922020-12-29 Regulating Intestinal Microbiota in the Prevention and Treatment of Alcohol-Related Liver Disease Chi, Xin Pan, Calvin Q. Liu, Shunai Cheng, Danying Cao, Ziwen Xing, Huichun Can J Gastroenterol Hepatol Review Article When alcohol-related liver disease occurs, the number and composition ratio of intestinal microorganisms will accordingly change. The alcohol-induced changes in the intestinal microbiota play a pivotal role in the process of developing the alcohol-related liver disease through the translocation of microbial products due to increased intestinal permeability. In recent years, therapeutic interventions with a concentration on regulating intestinal microbiota have been conducted for patients with alcohol-related liver disease. We aimed to provide a critical review and updates on the prevention and treatment of alcohol-related liver disease through regulating intestinal microbiota. A literature search was performed on the PubMed database for studies published in English about the therapeutic intervention with microbiota using animal models and patients with alcohol-related liver disease (1/2010–4/2020). The accumulating pieces of evidence suggest that the therapeutic use of probiotics, prebiotics, antibiotics, phages, or fecal microbial transplantation may have several influences on alcohol-related liver disease patients. Emergent data unveiled that these interventions can further regulate the composition of intestinal microbiota, minimize the negative impact of microbiota on the liver, and prevent disease progression from mild to severe alcoholic hepatitis, fibrosis, cirrhosis, or even liver cancer. The current review provides updates on the advances of therapeutic interventions with the effects of regulating intestinal microbiota on patients who have alcohol-related liver disease. In addition, the data gaps and research directions on further exploration of the role of intestinal microbiota for the management of the alcohol-related liver disease are also discussed. Hindawi 2020-12-17 /pmc/articles/PMC7759392/ /pubmed/33381475 http://dx.doi.org/10.1155/2020/6629196 Text en Copyright © 2020 Xin Chi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chi, Xin
Pan, Calvin Q.
Liu, Shunai
Cheng, Danying
Cao, Ziwen
Xing, Huichun
Regulating Intestinal Microbiota in the Prevention and Treatment of Alcohol-Related Liver Disease
title Regulating Intestinal Microbiota in the Prevention and Treatment of Alcohol-Related Liver Disease
title_full Regulating Intestinal Microbiota in the Prevention and Treatment of Alcohol-Related Liver Disease
title_fullStr Regulating Intestinal Microbiota in the Prevention and Treatment of Alcohol-Related Liver Disease
title_full_unstemmed Regulating Intestinal Microbiota in the Prevention and Treatment of Alcohol-Related Liver Disease
title_short Regulating Intestinal Microbiota in the Prevention and Treatment of Alcohol-Related Liver Disease
title_sort regulating intestinal microbiota in the prevention and treatment of alcohol-related liver disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759392/
https://www.ncbi.nlm.nih.gov/pubmed/33381475
http://dx.doi.org/10.1155/2020/6629196
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