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Development of a UPLC-MS/MS Method for the Quantification of VS-5584 and Its Application in Pharmacokinetic Studies in Rats

VS-5584 is a small-molecular compound that showed equivalent activity against mTOR and all class I PI3K isoforms and demonstrated preclinical activity in diverse cancer cell lines and xenograft tumor model, and rational combination of VS-5584 and other target therapies achieved promising outcomes in...

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Detalles Bibliográficos
Autores principales:	Zhou, Chunling, Li, Xiaoxin, He, Aiping, Liu, Tianzhu, Tian, Jinmiao, Jiang, Meihua, Fang, Lina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759402/ https://www.ncbi.nlm.nih.gov/pubmed/33381351 http://dx.doi.org/10.1155/2020/8811522

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