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Rehabilitation Before and After Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for Patients With Multiple Sclerosis (MS): Consensus Guidelines and Recommendations for Best Clinical Practice on Behalf of the Autoimmune Diseases Working Party, Nurses Group, and Patient Advocacy Committee of the European Society for Blood and Marrow Transplantation (EBMT)

Autologous haematopoietic stem cell transplantation (AHSCT) is increasingly used to treat people with multiple sclerosis (MS). Supported by an evolving evidence base, AHSCT can suppress active inflammation in the central nervous system and induce long-term changes in immune cell populations, thereby...

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Autores principales: Roberts, Fiona, Hobbs, Helen, Jessop, Helen, Bozzolini, Cristina, Burman, Joachim, Greco, Raffaella, Ismail, Azza, Kazmi, Majid, Kirgizov, Kirill, Mancardi, Gianluigi, Mawson, Susan, Muraro, Paolo A., Puyade, Mathieu, Saccardi, Riccardo, Withers, Barbara, Verhoeven, Bregje, Sharrack, Basil, Snowden, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759663/
https://www.ncbi.nlm.nih.gov/pubmed/33362684
http://dx.doi.org/10.3389/fneur.2020.556141
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author Roberts, Fiona
Hobbs, Helen
Jessop, Helen
Bozzolini, Cristina
Burman, Joachim
Greco, Raffaella
Ismail, Azza
Kazmi, Majid
Kirgizov, Kirill
Mancardi, Gianluigi
Mawson, Susan
Muraro, Paolo A.
Puyade, Mathieu
Saccardi, Riccardo
Withers, Barbara
Verhoeven, Bregje
Sharrack, Basil
Snowden, John A.
author_facet Roberts, Fiona
Hobbs, Helen
Jessop, Helen
Bozzolini, Cristina
Burman, Joachim
Greco, Raffaella
Ismail, Azza
Kazmi, Majid
Kirgizov, Kirill
Mancardi, Gianluigi
Mawson, Susan
Muraro, Paolo A.
Puyade, Mathieu
Saccardi, Riccardo
Withers, Barbara
Verhoeven, Bregje
Sharrack, Basil
Snowden, John A.
author_sort Roberts, Fiona
collection PubMed
description Autologous haematopoietic stem cell transplantation (AHSCT) is increasingly used to treat people with multiple sclerosis (MS). Supported by an evolving evidence base, AHSCT can suppress active inflammation in the central nervous system and induce long-term changes in immune cell populations, thereby stabilizing, and, in some cases, reversing disability in carefully selected MS patients. However, AHSCT is an intensive chemotherapy-based procedure associated with intrinsic risks, including profound cytopenia, infection, and organ toxicity, accompanied by an on-going degree of immuno-compromise and general deconditioning, which can be associated with a transient increase in functional impairment in the early stages after transplantation. Although international guidelines and recommendations have been published for clinical and technical aspects of AHSCT in MS, there has been no detailed appraisal of the rehabilitation needed following treatment nor any specific guidelines as to how this is best delivered by hospital and community-based therapists and wider multidisciplinary teams in order to maximize functional recovery and quality of life. These expert consensus guidelines aim to address this unmet need by summarizing the evidence-base for AHSCT in MS and providing recommendations for current rehabilitation practice along with identifying areas for future research and development.
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spelling pubmed-77596632020-12-26 Rehabilitation Before and After Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for Patients With Multiple Sclerosis (MS): Consensus Guidelines and Recommendations for Best Clinical Practice on Behalf of the Autoimmune Diseases Working Party, Nurses Group, and Patient Advocacy Committee of the European Society for Blood and Marrow Transplantation (EBMT) Roberts, Fiona Hobbs, Helen Jessop, Helen Bozzolini, Cristina Burman, Joachim Greco, Raffaella Ismail, Azza Kazmi, Majid Kirgizov, Kirill Mancardi, Gianluigi Mawson, Susan Muraro, Paolo A. Puyade, Mathieu Saccardi, Riccardo Withers, Barbara Verhoeven, Bregje Sharrack, Basil Snowden, John A. Front Neurol Neurology Autologous haematopoietic stem cell transplantation (AHSCT) is increasingly used to treat people with multiple sclerosis (MS). Supported by an evolving evidence base, AHSCT can suppress active inflammation in the central nervous system and induce long-term changes in immune cell populations, thereby stabilizing, and, in some cases, reversing disability in carefully selected MS patients. However, AHSCT is an intensive chemotherapy-based procedure associated with intrinsic risks, including profound cytopenia, infection, and organ toxicity, accompanied by an on-going degree of immuno-compromise and general deconditioning, which can be associated with a transient increase in functional impairment in the early stages after transplantation. Although international guidelines and recommendations have been published for clinical and technical aspects of AHSCT in MS, there has been no detailed appraisal of the rehabilitation needed following treatment nor any specific guidelines as to how this is best delivered by hospital and community-based therapists and wider multidisciplinary teams in order to maximize functional recovery and quality of life. These expert consensus guidelines aim to address this unmet need by summarizing the evidence-base for AHSCT in MS and providing recommendations for current rehabilitation practice along with identifying areas for future research and development. Frontiers Media S.A. 2020-12-11 /pmc/articles/PMC7759663/ /pubmed/33362684 http://dx.doi.org/10.3389/fneur.2020.556141 Text en Copyright © 2020 Roberts, Hobbs, Jessop, Bozzolini, Burman, Greco, Ismail, Kazmi, Kirgizov, Mancardi, Mawson, Muraro, Puyade, Saccardi, Withers, Verhoeven, Sharrack and Snowden. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Roberts, Fiona
Hobbs, Helen
Jessop, Helen
Bozzolini, Cristina
Burman, Joachim
Greco, Raffaella
Ismail, Azza
Kazmi, Majid
Kirgizov, Kirill
Mancardi, Gianluigi
Mawson, Susan
Muraro, Paolo A.
Puyade, Mathieu
Saccardi, Riccardo
Withers, Barbara
Verhoeven, Bregje
Sharrack, Basil
Snowden, John A.
Rehabilitation Before and After Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for Patients With Multiple Sclerosis (MS): Consensus Guidelines and Recommendations for Best Clinical Practice on Behalf of the Autoimmune Diseases Working Party, Nurses Group, and Patient Advocacy Committee of the European Society for Blood and Marrow Transplantation (EBMT)
title Rehabilitation Before and After Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for Patients With Multiple Sclerosis (MS): Consensus Guidelines and Recommendations for Best Clinical Practice on Behalf of the Autoimmune Diseases Working Party, Nurses Group, and Patient Advocacy Committee of the European Society for Blood and Marrow Transplantation (EBMT)
title_full Rehabilitation Before and After Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for Patients With Multiple Sclerosis (MS): Consensus Guidelines and Recommendations for Best Clinical Practice on Behalf of the Autoimmune Diseases Working Party, Nurses Group, and Patient Advocacy Committee of the European Society for Blood and Marrow Transplantation (EBMT)
title_fullStr Rehabilitation Before and After Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for Patients With Multiple Sclerosis (MS): Consensus Guidelines and Recommendations for Best Clinical Practice on Behalf of the Autoimmune Diseases Working Party, Nurses Group, and Patient Advocacy Committee of the European Society for Blood and Marrow Transplantation (EBMT)
title_full_unstemmed Rehabilitation Before and After Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for Patients With Multiple Sclerosis (MS): Consensus Guidelines and Recommendations for Best Clinical Practice on Behalf of the Autoimmune Diseases Working Party, Nurses Group, and Patient Advocacy Committee of the European Society for Blood and Marrow Transplantation (EBMT)
title_short Rehabilitation Before and After Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for Patients With Multiple Sclerosis (MS): Consensus Guidelines and Recommendations for Best Clinical Practice on Behalf of the Autoimmune Diseases Working Party, Nurses Group, and Patient Advocacy Committee of the European Society for Blood and Marrow Transplantation (EBMT)
title_sort rehabilitation before and after autologous haematopoietic stem cell transplantation (ahsct) for patients with multiple sclerosis (ms): consensus guidelines and recommendations for best clinical practice on behalf of the autoimmune diseases working party, nurses group, and patient advocacy committee of the european society for blood and marrow transplantation (ebmt)
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759663/
https://www.ncbi.nlm.nih.gov/pubmed/33362684
http://dx.doi.org/10.3389/fneur.2020.556141
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