Recurrent HyperCKemia with Immunological Involvement of the Endomysial Capillaries in Neuromyelitis Optica

A 55-year-old woman with neuromyelitis optica (NMO) had recurrent myalgias with hyperCKemia. A muscle biopsy suggested nonspecific myopathic changes. Regarding immunohistochemistry, the expression of both major histocompatibility complex class I and myxovirus resistance protein A was observed in the...

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Autores principales: Kinno, Ryuta, Osakabe, Yuyuko, Takahashi, Seiya, Kurokawa, Shinji, Owan, Yoshiyuki, Shimizu, Jun, Ono, Kenjiro, Baba, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759704/
https://www.ncbi.nlm.nih.gov/pubmed/32759582
http://dx.doi.org/10.2169/internalmedicine.4600-20
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author Kinno, Ryuta
Osakabe, Yuyuko
Takahashi, Seiya
Kurokawa, Shinji
Owan, Yoshiyuki
Shimizu, Jun
Ono, Kenjiro
Baba, Yasuhiko
author_facet Kinno, Ryuta
Osakabe, Yuyuko
Takahashi, Seiya
Kurokawa, Shinji
Owan, Yoshiyuki
Shimizu, Jun
Ono, Kenjiro
Baba, Yasuhiko
author_sort Kinno, Ryuta
collection PubMed
description A 55-year-old woman with neuromyelitis optica (NMO) had recurrent myalgias with hyperCKemia. A muscle biopsy suggested nonspecific myopathic changes. Regarding immunohistochemistry, the expression of both major histocompatibility complex class I and myxovirus resistance protein A was observed in the endomysial capillaries, suggesting immunological involvement of these capillaries, whereas both C5b9 (membrane attack complex) and aquaporin 4 immunofluorescence stainings were normal. The present findings led us to conclude that one possible mechanism for hyperCKemia in NMO underlying the immunological involvement of the endomysial capillaries was an as-yet-unidentified factor that triggered damage to the integrity of the sarcolemma and thereby cause CK leakage into the serum.
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spelling pubmed-77597042020-12-31 Recurrent HyperCKemia with Immunological Involvement of the Endomysial Capillaries in Neuromyelitis Optica Kinno, Ryuta Osakabe, Yuyuko Takahashi, Seiya Kurokawa, Shinji Owan, Yoshiyuki Shimizu, Jun Ono, Kenjiro Baba, Yasuhiko Intern Med Case Report A 55-year-old woman with neuromyelitis optica (NMO) had recurrent myalgias with hyperCKemia. A muscle biopsy suggested nonspecific myopathic changes. Regarding immunohistochemistry, the expression of both major histocompatibility complex class I and myxovirus resistance protein A was observed in the endomysial capillaries, suggesting immunological involvement of these capillaries, whereas both C5b9 (membrane attack complex) and aquaporin 4 immunofluorescence stainings were normal. The present findings led us to conclude that one possible mechanism for hyperCKemia in NMO underlying the immunological involvement of the endomysial capillaries was an as-yet-unidentified factor that triggered damage to the integrity of the sarcolemma and thereby cause CK leakage into the serum. The Japanese Society of Internal Medicine 2020-08-04 2020-12-01 /pmc/articles/PMC7759704/ /pubmed/32759582 http://dx.doi.org/10.2169/internalmedicine.4600-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kinno, Ryuta
Osakabe, Yuyuko
Takahashi, Seiya
Kurokawa, Shinji
Owan, Yoshiyuki
Shimizu, Jun
Ono, Kenjiro
Baba, Yasuhiko
Recurrent HyperCKemia with Immunological Involvement of the Endomysial Capillaries in Neuromyelitis Optica
title Recurrent HyperCKemia with Immunological Involvement of the Endomysial Capillaries in Neuromyelitis Optica
title_full Recurrent HyperCKemia with Immunological Involvement of the Endomysial Capillaries in Neuromyelitis Optica
title_fullStr Recurrent HyperCKemia with Immunological Involvement of the Endomysial Capillaries in Neuromyelitis Optica
title_full_unstemmed Recurrent HyperCKemia with Immunological Involvement of the Endomysial Capillaries in Neuromyelitis Optica
title_short Recurrent HyperCKemia with Immunological Involvement of the Endomysial Capillaries in Neuromyelitis Optica
title_sort recurrent hyperckemia with immunological involvement of the endomysial capillaries in neuromyelitis optica
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759704/
https://www.ncbi.nlm.nih.gov/pubmed/32759582
http://dx.doi.org/10.2169/internalmedicine.4600-20
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