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Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin

We herein report a 33-year-old woman who was an asymptomatic hepatitis B virus (HBV) carrier and presented with distal muscle weakness in the legs and asymmetrical paresthesia in the distal extremities. A nerve biopsy specimen revealed fibrinoid necrosis associated with inflammatory infiltration in...

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Autores principales: Kusama, Kaori, Nakae, Yoshiharu, Tada, Mikiko, Higashiyama, Yuichi, Miyaji, Yosuke, Yamaura, Genpei, Kunii, Misako, Tanaka, Kenichi, Ohyama, Ken, Koike, Haruki, Joki, Hideto, Doi, Hiroshi, Koyano, Shigeru, Tanaka, Fumiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759712/
https://www.ncbi.nlm.nih.gov/pubmed/32759579
http://dx.doi.org/10.2169/internalmedicine.4498-20
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author Kusama, Kaori
Nakae, Yoshiharu
Tada, Mikiko
Higashiyama, Yuichi
Miyaji, Yosuke
Yamaura, Genpei
Kunii, Misako
Tanaka, Kenichi
Ohyama, Ken
Koike, Haruki
Joki, Hideto
Doi, Hiroshi
Koyano, Shigeru
Tanaka, Fumiaki
author_facet Kusama, Kaori
Nakae, Yoshiharu
Tada, Mikiko
Higashiyama, Yuichi
Miyaji, Yosuke
Yamaura, Genpei
Kunii, Misako
Tanaka, Kenichi
Ohyama, Ken
Koike, Haruki
Joki, Hideto
Doi, Hiroshi
Koyano, Shigeru
Tanaka, Fumiaki
author_sort Kusama, Kaori
collection PubMed
description We herein report a 33-year-old woman who was an asymptomatic hepatitis B virus (HBV) carrier and presented with distal muscle weakness in the legs and asymmetrical paresthesia in the distal extremities. A nerve biopsy specimen revealed fibrinoid necrosis associated with inflammatory infiltration in the perineural space, and deposition of hepatitis B core antigen and C4d complement was detected in the vascular endothelial cells as well as around the vessels. She was diagnosed with HBV-related vasculitic neuropathy and treated with intravenous immunoglobulin (IVIG). Her symptoms completely subsided after eight weeks. Vasculitic neuropathy rarely develops in the chronic inactive stages of HBV infection. This is the first report of an HBV-inactive carrier with vasculitic neuropathy successfully treated with IVIG.
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spelling pubmed-77597122020-12-31 Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin Kusama, Kaori Nakae, Yoshiharu Tada, Mikiko Higashiyama, Yuichi Miyaji, Yosuke Yamaura, Genpei Kunii, Misako Tanaka, Kenichi Ohyama, Ken Koike, Haruki Joki, Hideto Doi, Hiroshi Koyano, Shigeru Tanaka, Fumiaki Intern Med Case Report We herein report a 33-year-old woman who was an asymptomatic hepatitis B virus (HBV) carrier and presented with distal muscle weakness in the legs and asymmetrical paresthesia in the distal extremities. A nerve biopsy specimen revealed fibrinoid necrosis associated with inflammatory infiltration in the perineural space, and deposition of hepatitis B core antigen and C4d complement was detected in the vascular endothelial cells as well as around the vessels. She was diagnosed with HBV-related vasculitic neuropathy and treated with intravenous immunoglobulin (IVIG). Her symptoms completely subsided after eight weeks. Vasculitic neuropathy rarely develops in the chronic inactive stages of HBV infection. This is the first report of an HBV-inactive carrier with vasculitic neuropathy successfully treated with IVIG. The Japanese Society of Internal Medicine 2020-08-04 2020-12-01 /pmc/articles/PMC7759712/ /pubmed/32759579 http://dx.doi.org/10.2169/internalmedicine.4498-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kusama, Kaori
Nakae, Yoshiharu
Tada, Mikiko
Higashiyama, Yuichi
Miyaji, Yosuke
Yamaura, Genpei
Kunii, Misako
Tanaka, Kenichi
Ohyama, Ken
Koike, Haruki
Joki, Hideto
Doi, Hiroshi
Koyano, Shigeru
Tanaka, Fumiaki
Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin
title Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin
title_full Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin
title_fullStr Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin
title_full_unstemmed Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin
title_short Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin
title_sort hepatitis b virus-related vasculitic neuropathy in an inactive virus carrier treated with intravenous immunoglobulin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759712/
https://www.ncbi.nlm.nih.gov/pubmed/32759579
http://dx.doi.org/10.2169/internalmedicine.4498-20
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