Cargando…
Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin
We herein report a 33-year-old woman who was an asymptomatic hepatitis B virus (HBV) carrier and presented with distal muscle weakness in the legs and asymmetrical paresthesia in the distal extremities. A nerve biopsy specimen revealed fibrinoid necrosis associated with inflammatory infiltration in...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759712/ https://www.ncbi.nlm.nih.gov/pubmed/32759579 http://dx.doi.org/10.2169/internalmedicine.4498-20 |
_version_ | 1783627165555752960 |
---|---|
author | Kusama, Kaori Nakae, Yoshiharu Tada, Mikiko Higashiyama, Yuichi Miyaji, Yosuke Yamaura, Genpei Kunii, Misako Tanaka, Kenichi Ohyama, Ken Koike, Haruki Joki, Hideto Doi, Hiroshi Koyano, Shigeru Tanaka, Fumiaki |
author_facet | Kusama, Kaori Nakae, Yoshiharu Tada, Mikiko Higashiyama, Yuichi Miyaji, Yosuke Yamaura, Genpei Kunii, Misako Tanaka, Kenichi Ohyama, Ken Koike, Haruki Joki, Hideto Doi, Hiroshi Koyano, Shigeru Tanaka, Fumiaki |
author_sort | Kusama, Kaori |
collection | PubMed |
description | We herein report a 33-year-old woman who was an asymptomatic hepatitis B virus (HBV) carrier and presented with distal muscle weakness in the legs and asymmetrical paresthesia in the distal extremities. A nerve biopsy specimen revealed fibrinoid necrosis associated with inflammatory infiltration in the perineural space, and deposition of hepatitis B core antigen and C4d complement was detected in the vascular endothelial cells as well as around the vessels. She was diagnosed with HBV-related vasculitic neuropathy and treated with intravenous immunoglobulin (IVIG). Her symptoms completely subsided after eight weeks. Vasculitic neuropathy rarely develops in the chronic inactive stages of HBV infection. This is the first report of an HBV-inactive carrier with vasculitic neuropathy successfully treated with IVIG. |
format | Online Article Text |
id | pubmed-7759712 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-77597122020-12-31 Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin Kusama, Kaori Nakae, Yoshiharu Tada, Mikiko Higashiyama, Yuichi Miyaji, Yosuke Yamaura, Genpei Kunii, Misako Tanaka, Kenichi Ohyama, Ken Koike, Haruki Joki, Hideto Doi, Hiroshi Koyano, Shigeru Tanaka, Fumiaki Intern Med Case Report We herein report a 33-year-old woman who was an asymptomatic hepatitis B virus (HBV) carrier and presented with distal muscle weakness in the legs and asymmetrical paresthesia in the distal extremities. A nerve biopsy specimen revealed fibrinoid necrosis associated with inflammatory infiltration in the perineural space, and deposition of hepatitis B core antigen and C4d complement was detected in the vascular endothelial cells as well as around the vessels. She was diagnosed with HBV-related vasculitic neuropathy and treated with intravenous immunoglobulin (IVIG). Her symptoms completely subsided after eight weeks. Vasculitic neuropathy rarely develops in the chronic inactive stages of HBV infection. This is the first report of an HBV-inactive carrier with vasculitic neuropathy successfully treated with IVIG. The Japanese Society of Internal Medicine 2020-08-04 2020-12-01 /pmc/articles/PMC7759712/ /pubmed/32759579 http://dx.doi.org/10.2169/internalmedicine.4498-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Kusama, Kaori Nakae, Yoshiharu Tada, Mikiko Higashiyama, Yuichi Miyaji, Yosuke Yamaura, Genpei Kunii, Misako Tanaka, Kenichi Ohyama, Ken Koike, Haruki Joki, Hideto Doi, Hiroshi Koyano, Shigeru Tanaka, Fumiaki Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin |
title | Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin |
title_full | Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin |
title_fullStr | Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin |
title_full_unstemmed | Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin |
title_short | Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin |
title_sort | hepatitis b virus-related vasculitic neuropathy in an inactive virus carrier treated with intravenous immunoglobulin |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759712/ https://www.ncbi.nlm.nih.gov/pubmed/32759579 http://dx.doi.org/10.2169/internalmedicine.4498-20 |
work_keys_str_mv | AT kusamakaori hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin AT nakaeyoshiharu hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin AT tadamikiko hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin AT higashiyamayuichi hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin AT miyajiyosuke hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin AT yamauragenpei hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin AT kuniimisako hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin AT tanakakenichi hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin AT ohyamaken hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin AT koikeharuki hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin AT jokihideto hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin AT doihiroshi hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin AT koyanoshigeru hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin AT tanakafumiaki hepatitisbvirusrelatedvasculiticneuropathyinaninactiveviruscarriertreatedwithintravenousimmunoglobulin |