Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors

The dual functionalization of magnetic nanoparticles with inert (methyl) and reactive (aminopropyl) groups enables efficient immobilization of synthetic metalloporphyrins (such as 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin and 5,10,15,20-tetrakis-(4-sulfonatophenyl)iron(II) p...

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Autores principales: Balogh-Weiser, Diána, Decsi, Balázs, Krammer, Réka, Dargó, Gergő, Ender, Ferenc, Mizsei, János, Berkecz, Róbert, Gyarmati, Benjámin, Szilágyi, András, Tőtős, Róbert, Paizs, Csaba, Poppe, László, Balogh, György T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759782/
https://www.ncbi.nlm.nih.gov/pubmed/33255480
http://dx.doi.org/10.3390/nano10122329
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author Balogh-Weiser, Diána
Decsi, Balázs
Krammer, Réka
Dargó, Gergő
Ender, Ferenc
Mizsei, János
Berkecz, Róbert
Gyarmati, Benjámin
Szilágyi, András
Tőtős, Róbert
Paizs, Csaba
Poppe, László
Balogh, György T.
author_facet Balogh-Weiser, Diána
Decsi, Balázs
Krammer, Réka
Dargó, Gergő
Ender, Ferenc
Mizsei, János
Berkecz, Róbert
Gyarmati, Benjámin
Szilágyi, András
Tőtős, Róbert
Paizs, Csaba
Poppe, László
Balogh, György T.
author_sort Balogh-Weiser, Diána
collection PubMed
description The dual functionalization of magnetic nanoparticles with inert (methyl) and reactive (aminopropyl) groups enables efficient immobilization of synthetic metalloporphyrins (such as 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin and 5,10,15,20-tetrakis-(4-sulfonatophenyl)iron(II) porphyrin) via covalent or ionic interactions. The proportion of reactive function on the surface has significant effect on the biomimetic activity of metalloporphyrins. The optimized magnetic nanocatalyst containing porphyrin was successfully applied for biomimetic oxidation of antihypertensive drug Amlodipine in batch and continuous-flow reactors as well.
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spelling pubmed-77597822020-12-26 Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors Balogh-Weiser, Diána Decsi, Balázs Krammer, Réka Dargó, Gergő Ender, Ferenc Mizsei, János Berkecz, Róbert Gyarmati, Benjámin Szilágyi, András Tőtős, Róbert Paizs, Csaba Poppe, László Balogh, György T. Nanomaterials (Basel) Article The dual functionalization of magnetic nanoparticles with inert (methyl) and reactive (aminopropyl) groups enables efficient immobilization of synthetic metalloporphyrins (such as 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin and 5,10,15,20-tetrakis-(4-sulfonatophenyl)iron(II) porphyrin) via covalent or ionic interactions. The proportion of reactive function on the surface has significant effect on the biomimetic activity of metalloporphyrins. The optimized magnetic nanocatalyst containing porphyrin was successfully applied for biomimetic oxidation of antihypertensive drug Amlodipine in batch and continuous-flow reactors as well. MDPI 2020-11-24 /pmc/articles/PMC7759782/ /pubmed/33255480 http://dx.doi.org/10.3390/nano10122329 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Balogh-Weiser, Diána
Decsi, Balázs
Krammer, Réka
Dargó, Gergő
Ender, Ferenc
Mizsei, János
Berkecz, Róbert
Gyarmati, Benjámin
Szilágyi, András
Tőtős, Róbert
Paizs, Csaba
Poppe, László
Balogh, György T.
Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors
title Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors
title_full Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors
title_fullStr Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors
title_full_unstemmed Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors
title_short Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors
title_sort magnetic nanoparticles with dual surface functions—efficient carriers for metalloporphyrin-catalyzed drug metabolite synthesis in batch and continuous-flow reactors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759782/
https://www.ncbi.nlm.nih.gov/pubmed/33255480
http://dx.doi.org/10.3390/nano10122329
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