Animal Safety, Toxicology, and Pharmacokinetic Studies According to the ICH S9 Guideline for a Novel Fusion Protein tTF-NGR Targeting Procoagulatory Activity into Tumor Vasculature: Are Results Predictive for Humans?

SIMPLE SUMMARY: Non-clinical safety, toxicology, and pharmacokinetic studies according to ICH guidelines with a new fusion protein tTF-NGR consisting of human truncated tissue factor (TF) and a small targeting peptide are reported. Results are compared with those of a phase I clinical dose escalatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Berdel, Wolfgang E., Harrach, Saliha, Brand, Caroline, Brömmel, Kathrin, Berdel, Andrew F., Hintelmann, Heike, Schliemann, Christoph, Schwöppe, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759859/
https://www.ncbi.nlm.nih.gov/pubmed/33256235
http://dx.doi.org/10.3390/cancers12123536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759859/
https://www.ncbi.nlm.nih.gov/pubmed/33256235
http://dx.doi.org/10.3390/cancers12123536

Ejemplares similares