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Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma

Purpose: The pattern electroretinogram (PERG) is useful to detect retinal ganglion cell (RGC) damage in patients with glaucoma. Optical coherence tomography angiography (OCTA) measures retinal vessel density (VD), which is known to be reduced in glaucoma. There may be correlations between parameters...

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Autores principales: Lee, Taekjune, Seo, Du Ri, Kim, Joo Yeon, Choi, Wungrak, Lee, Sang Yeop, Lee, Jun Mo, Seong, Gong Je, Kim, Chan Yun, Bae, Hyoung Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759986/
https://www.ncbi.nlm.nih.gov/pubmed/33260929
http://dx.doi.org/10.3390/jcm9123854
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author Lee, Taekjune
Seo, Du Ri
Kim, Joo Yeon
Choi, Wungrak
Lee, Sang Yeop
Lee, Jun Mo
Seong, Gong Je
Kim, Chan Yun
Bae, Hyoung Won
author_facet Lee, Taekjune
Seo, Du Ri
Kim, Joo Yeon
Choi, Wungrak
Lee, Sang Yeop
Lee, Jun Mo
Seong, Gong Je
Kim, Chan Yun
Bae, Hyoung Won
author_sort Lee, Taekjune
collection PubMed
description Purpose: The pattern electroretinogram (PERG) is useful to detect retinal ganglion cell (RGC) damage in patients with glaucoma. Optical coherence tomography angiography (OCTA) measures retinal vessel density (VD), which is known to be reduced in glaucoma. There may be correlations between parameters of the PERG and OCTA in open-angle glaucoma (OAG). Methods: In total, 95 eyes of 95 OAG patients and 102 eyes of 102 normal controls were included in this study. N35, P50, and N95 latency along with P50 and N95 amplitude were obtained using the PERG. Retinal VD was measured around the peripapillary and macular area according to the ETDRS grid (concentric circles with diameters of 1, 3, and 6 mm), which is named a center (≤1 mm), an inner (1–3 mm), an outer (3–6 mm), and a full (≤6 mm) area. Pearson correlation analysis was done between parameters, and partial correlation analysis was done after adjusting confounding factors. Results: P50 amplitude, N95 amplitude, and VD of most measured areas were significantly lower in the OAG group compared to the normal group. N95 amplitude showed a statistically significant correlation with parameters of optical coherence tomography and visual field, peripapillary outer and full VD, and macular outer and full VD even after adjusting confounding factors. There was no significant correlation between parameters in the normal group. Conclusions: N95 amplitude was associated with structural and functional change including VD reduction in OAG. Microvascular alterations may be associated with dysfunctional changes of RGC recorded by the PERG in OAG.
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spelling pubmed-77599862020-12-26 Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma Lee, Taekjune Seo, Du Ri Kim, Joo Yeon Choi, Wungrak Lee, Sang Yeop Lee, Jun Mo Seong, Gong Je Kim, Chan Yun Bae, Hyoung Won J Clin Med Article Purpose: The pattern electroretinogram (PERG) is useful to detect retinal ganglion cell (RGC) damage in patients with glaucoma. Optical coherence tomography angiography (OCTA) measures retinal vessel density (VD), which is known to be reduced in glaucoma. There may be correlations between parameters of the PERG and OCTA in open-angle glaucoma (OAG). Methods: In total, 95 eyes of 95 OAG patients and 102 eyes of 102 normal controls were included in this study. N35, P50, and N95 latency along with P50 and N95 amplitude were obtained using the PERG. Retinal VD was measured around the peripapillary and macular area according to the ETDRS grid (concentric circles with diameters of 1, 3, and 6 mm), which is named a center (≤1 mm), an inner (1–3 mm), an outer (3–6 mm), and a full (≤6 mm) area. Pearson correlation analysis was done between parameters, and partial correlation analysis was done after adjusting confounding factors. Results: P50 amplitude, N95 amplitude, and VD of most measured areas were significantly lower in the OAG group compared to the normal group. N95 amplitude showed a statistically significant correlation with parameters of optical coherence tomography and visual field, peripapillary outer and full VD, and macular outer and full VD even after adjusting confounding factors. There was no significant correlation between parameters in the normal group. Conclusions: N95 amplitude was associated with structural and functional change including VD reduction in OAG. Microvascular alterations may be associated with dysfunctional changes of RGC recorded by the PERG in OAG. MDPI 2020-11-27 /pmc/articles/PMC7759986/ /pubmed/33260929 http://dx.doi.org/10.3390/jcm9123854 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Taekjune
Seo, Du Ri
Kim, Joo Yeon
Choi, Wungrak
Lee, Sang Yeop
Lee, Jun Mo
Seong, Gong Je
Kim, Chan Yun
Bae, Hyoung Won
Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma
title Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma
title_full Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma
title_fullStr Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma
title_full_unstemmed Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma
title_short Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma
title_sort relationship between n95 amplitude of pattern electroretinogram and optical coherence tomography angiography in open-angle glaucoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759986/
https://www.ncbi.nlm.nih.gov/pubmed/33260929
http://dx.doi.org/10.3390/jcm9123854
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