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Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins

While an adequate protein intake is important for the maintenance of muscle mass during ageing, the amount and source of protein necessary for optimal prevention of sarcopenia remains to be determined. The present study aimed to investigate the influence of the amount and source of dietary proteins...

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Autores principales: Montiel-Rojas, Diego, Nilsson, Andreas, Santoro, Aurelia, Bazzocchi, Alberto, de Groot, Lisette C. P. G. M., Feskens, Edith J. M., Berendsen, Agnes A. M., Madej, Dawid, Kaluza, Joanna, Pietruszka, Barbara, Jennings, Amy, Fairweather-Tait, Susan, Battista, Giuseppe, Capri, Miriam, Franceschi, Claudio, Kadi, Fawzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760110/
https://www.ncbi.nlm.nih.gov/pubmed/33255223
http://dx.doi.org/10.3390/nu12123601
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author Montiel-Rojas, Diego
Nilsson, Andreas
Santoro, Aurelia
Bazzocchi, Alberto
de Groot, Lisette C. P. G. M.
Feskens, Edith J. M.
Berendsen, Agnes A. M.
Madej, Dawid
Kaluza, Joanna
Pietruszka, Barbara
Jennings, Amy
Fairweather-Tait, Susan
Battista, Giuseppe
Capri, Miriam
Franceschi, Claudio
Kadi, Fawzi
author_facet Montiel-Rojas, Diego
Nilsson, Andreas
Santoro, Aurelia
Bazzocchi, Alberto
de Groot, Lisette C. P. G. M.
Feskens, Edith J. M.
Berendsen, Agnes A. M.
Madej, Dawid
Kaluza, Joanna
Pietruszka, Barbara
Jennings, Amy
Fairweather-Tait, Susan
Battista, Giuseppe
Capri, Miriam
Franceschi, Claudio
Kadi, Fawzi
author_sort Montiel-Rojas, Diego
collection PubMed
description While an adequate protein intake is important for the maintenance of muscle mass during ageing, the amount and source of protein necessary for optimal prevention of sarcopenia remains to be determined. The present study aimed to investigate the influence of the amount and source of dietary proteins on sarcopenia risk in a cohort of 65–79-year-old European adults within the frame of the NU-AGE study. A total of 986 participants were included in the analysis. Skeletal muscle index (SMI), assessed by dual-energy X-ray absorptiometry (DXA), and handgrip strength (HG) were employed to create a continuous sex-specific sarcopenia risk score (SRS). Total amount together with animal- and plant-derived sources of proteins were obtained from a 7-day food record. Differences in SRS were analysed across groups of total protein intake (<0.8 g/body weight (BW); 0.8–<1.0 g/BW; 1.0–<1.2 g/BW; and ≥1.2 g/BW). The association between SRS and the different sources of protein was assessed using isocaloric substitution models adjusted by demographic, medical, and lifestyle factors. A significant linear dose-response relationship was observed, with a lower SRS linked to higher protein intakes. Based on the isocaloric substitution modelling, a reduced SRS was observed when increasing plant protein to the detriment of animal protein, while holding total protein intake constant. Further, this result remained significant after stratifying the analysis by adherence to different levels of protein intake. Our findings suggest that older adults may benefit from increasing protein intakes above current recommendations. Besides total amount, protein source should be considered when promoting health dietary habits in older adults for the prevention of sarcopenia.
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spelling pubmed-77601102020-12-26 Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins Montiel-Rojas, Diego Nilsson, Andreas Santoro, Aurelia Bazzocchi, Alberto de Groot, Lisette C. P. G. M. Feskens, Edith J. M. Berendsen, Agnes A. M. Madej, Dawid Kaluza, Joanna Pietruszka, Barbara Jennings, Amy Fairweather-Tait, Susan Battista, Giuseppe Capri, Miriam Franceschi, Claudio Kadi, Fawzi Nutrients Article While an adequate protein intake is important for the maintenance of muscle mass during ageing, the amount and source of protein necessary for optimal prevention of sarcopenia remains to be determined. The present study aimed to investigate the influence of the amount and source of dietary proteins on sarcopenia risk in a cohort of 65–79-year-old European adults within the frame of the NU-AGE study. A total of 986 participants were included in the analysis. Skeletal muscle index (SMI), assessed by dual-energy X-ray absorptiometry (DXA), and handgrip strength (HG) were employed to create a continuous sex-specific sarcopenia risk score (SRS). Total amount together with animal- and plant-derived sources of proteins were obtained from a 7-day food record. Differences in SRS were analysed across groups of total protein intake (<0.8 g/body weight (BW); 0.8–<1.0 g/BW; 1.0–<1.2 g/BW; and ≥1.2 g/BW). The association between SRS and the different sources of protein was assessed using isocaloric substitution models adjusted by demographic, medical, and lifestyle factors. A significant linear dose-response relationship was observed, with a lower SRS linked to higher protein intakes. Based on the isocaloric substitution modelling, a reduced SRS was observed when increasing plant protein to the detriment of animal protein, while holding total protein intake constant. Further, this result remained significant after stratifying the analysis by adherence to different levels of protein intake. Our findings suggest that older adults may benefit from increasing protein intakes above current recommendations. Besides total amount, protein source should be considered when promoting health dietary habits in older adults for the prevention of sarcopenia. MDPI 2020-11-24 /pmc/articles/PMC7760110/ /pubmed/33255223 http://dx.doi.org/10.3390/nu12123601 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Montiel-Rojas, Diego
Nilsson, Andreas
Santoro, Aurelia
Bazzocchi, Alberto
de Groot, Lisette C. P. G. M.
Feskens, Edith J. M.
Berendsen, Agnes A. M.
Madej, Dawid
Kaluza, Joanna
Pietruszka, Barbara
Jennings, Amy
Fairweather-Tait, Susan
Battista, Giuseppe
Capri, Miriam
Franceschi, Claudio
Kadi, Fawzi
Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins
title Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins
title_full Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins
title_fullStr Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins
title_full_unstemmed Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins
title_short Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins
title_sort fighting sarcopenia in ageing european adults: the importance of the amount and source of dietary proteins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760110/
https://www.ncbi.nlm.nih.gov/pubmed/33255223
http://dx.doi.org/10.3390/nu12123601
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