Cargando…
Clinical Applications of Mesenchymal Stem/Stromal Cell Derived Extracellular Vesicles: Therapeutic Potential of an Acellular Product
In the last decade, the secreting activity of mesenchymal stem/stromal cells (MSCs) has been widely investigated, due to its possible therapeutic role. In fact, MSCs release extracellular vesicles (EVs) containing relevant biomolecules such as mRNAs, microRNAs, bioactive lipids, and signaling recept...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760121/ https://www.ncbi.nlm.nih.gov/pubmed/33255416 http://dx.doi.org/10.3390/diagnostics10120999 |
_version_ | 1783627257703563264 |
---|---|
author | Massa, Margherita Croce, Stefania Campanelli, Rita Abbà, Carlotta Lenta, Elisa Valsecchi, Chiara Avanzini, Maria Antonietta |
author_facet | Massa, Margherita Croce, Stefania Campanelli, Rita Abbà, Carlotta Lenta, Elisa Valsecchi, Chiara Avanzini, Maria Antonietta |
author_sort | Massa, Margherita |
collection | PubMed |
description | In the last decade, the secreting activity of mesenchymal stem/stromal cells (MSCs) has been widely investigated, due to its possible therapeutic role. In fact, MSCs release extracellular vesicles (EVs) containing relevant biomolecules such as mRNAs, microRNAs, bioactive lipids, and signaling receptors, able to restore physiological conditions where regenerative or anti-inflammatory actions are needed. An actual advantage would come from the therapeutic use of EVs with respect to MSCs, avoiding the possible immune rejection, the lung entrapment, improving the safety, and allowing the crossing of biological barriers. A number of concerns still have to be solved regarding the mechanisms determining the beneficial effect of MSC-EVs, the possible alteration of their properties as a consequence of the isolation/purification methods, and/or the best approach for a large-scale production for clinical use. Most of the preclinical studies have been successful, reporting for MSC-EVs a protecting role in acute kidney injury following ischemia reperfusion, a potent anti-inflammatory and anti-fibrotic effects by reducing disease associated inflammation and fibrosis in lung and liver, and the modulation of both innate and adaptive immune responses in graft versus host disease (GVHD) as well as autoimmune diseases. However, the translation of MSC-EVs to the clinical stage is still at the initial phase. Herein, we discuss the therapeutic potential of an acellular product such as MSC derived EVs (MSC-EVs) in acute and chronic pathologies. |
format | Online Article Text |
id | pubmed-7760121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77601212020-12-26 Clinical Applications of Mesenchymal Stem/Stromal Cell Derived Extracellular Vesicles: Therapeutic Potential of an Acellular Product Massa, Margherita Croce, Stefania Campanelli, Rita Abbà, Carlotta Lenta, Elisa Valsecchi, Chiara Avanzini, Maria Antonietta Diagnostics (Basel) Review In the last decade, the secreting activity of mesenchymal stem/stromal cells (MSCs) has been widely investigated, due to its possible therapeutic role. In fact, MSCs release extracellular vesicles (EVs) containing relevant biomolecules such as mRNAs, microRNAs, bioactive lipids, and signaling receptors, able to restore physiological conditions where regenerative or anti-inflammatory actions are needed. An actual advantage would come from the therapeutic use of EVs with respect to MSCs, avoiding the possible immune rejection, the lung entrapment, improving the safety, and allowing the crossing of biological barriers. A number of concerns still have to be solved regarding the mechanisms determining the beneficial effect of MSC-EVs, the possible alteration of their properties as a consequence of the isolation/purification methods, and/or the best approach for a large-scale production for clinical use. Most of the preclinical studies have been successful, reporting for MSC-EVs a protecting role in acute kidney injury following ischemia reperfusion, a potent anti-inflammatory and anti-fibrotic effects by reducing disease associated inflammation and fibrosis in lung and liver, and the modulation of both innate and adaptive immune responses in graft versus host disease (GVHD) as well as autoimmune diseases. However, the translation of MSC-EVs to the clinical stage is still at the initial phase. Herein, we discuss the therapeutic potential of an acellular product such as MSC derived EVs (MSC-EVs) in acute and chronic pathologies. MDPI 2020-11-24 /pmc/articles/PMC7760121/ /pubmed/33255416 http://dx.doi.org/10.3390/diagnostics10120999 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Massa, Margherita Croce, Stefania Campanelli, Rita Abbà, Carlotta Lenta, Elisa Valsecchi, Chiara Avanzini, Maria Antonietta Clinical Applications of Mesenchymal Stem/Stromal Cell Derived Extracellular Vesicles: Therapeutic Potential of an Acellular Product |
title | Clinical Applications of Mesenchymal Stem/Stromal Cell Derived Extracellular Vesicles: Therapeutic Potential of an Acellular Product |
title_full | Clinical Applications of Mesenchymal Stem/Stromal Cell Derived Extracellular Vesicles: Therapeutic Potential of an Acellular Product |
title_fullStr | Clinical Applications of Mesenchymal Stem/Stromal Cell Derived Extracellular Vesicles: Therapeutic Potential of an Acellular Product |
title_full_unstemmed | Clinical Applications of Mesenchymal Stem/Stromal Cell Derived Extracellular Vesicles: Therapeutic Potential of an Acellular Product |
title_short | Clinical Applications of Mesenchymal Stem/Stromal Cell Derived Extracellular Vesicles: Therapeutic Potential of an Acellular Product |
title_sort | clinical applications of mesenchymal stem/stromal cell derived extracellular vesicles: therapeutic potential of an acellular product |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760121/ https://www.ncbi.nlm.nih.gov/pubmed/33255416 http://dx.doi.org/10.3390/diagnostics10120999 |
work_keys_str_mv | AT massamargherita clinicalapplicationsofmesenchymalstemstromalcellderivedextracellularvesiclestherapeuticpotentialofanacellularproduct AT crocestefania clinicalapplicationsofmesenchymalstemstromalcellderivedextracellularvesiclestherapeuticpotentialofanacellularproduct AT campanellirita clinicalapplicationsofmesenchymalstemstromalcellderivedextracellularvesiclestherapeuticpotentialofanacellularproduct AT abbacarlotta clinicalapplicationsofmesenchymalstemstromalcellderivedextracellularvesiclestherapeuticpotentialofanacellularproduct AT lentaelisa clinicalapplicationsofmesenchymalstemstromalcellderivedextracellularvesiclestherapeuticpotentialofanacellularproduct AT valsecchichiara clinicalapplicationsofmesenchymalstemstromalcellderivedextracellularvesiclestherapeuticpotentialofanacellularproduct AT avanzinimariaantonietta clinicalapplicationsofmesenchymalstemstromalcellderivedextracellularvesiclestherapeuticpotentialofanacellularproduct |