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BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes

Amyloid formation plays a major role in a number of neurodegenerative diseases, including Alzheimer’s disease. Amyloid-β peptides (Aβ) are one of the primary markers associated with this pathology. Aβ aggregates exhibit a diverse range of morphologies with distinct pathological activities. Recogniti...

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Autor principal: Dzyuba, Sergei V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760207/
https://www.ncbi.nlm.nih.gov/pubmed/33260945
http://dx.doi.org/10.3390/bios10120192
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author Dzyuba, Sergei V.
author_facet Dzyuba, Sergei V.
author_sort Dzyuba, Sergei V.
collection PubMed
description Amyloid formation plays a major role in a number of neurodegenerative diseases, including Alzheimer’s disease. Amyloid-β peptides (Aβ) are one of the primary markers associated with this pathology. Aβ aggregates exhibit a diverse range of morphologies with distinct pathological activities. Recognition of the Aβ aggregates by using small molecule-based probes and sensors should not only enhance understanding of the underlying mechanisms of amyloid formation, but also facilitate the development of therapeutic strategies to interfere with amyloid neurotoxicity. BODIPY (boron dipyrrin) dyes are among the most versatile small molecule fluorophores. BODIPY scaffolds could be functionalized to tune their photophysical properties to the desired ranges as well as to adapt these dyes to various types of conditions and environments. Thus, BODIPY dyes could be viewed as unique platforms for the design of probes and sensors that are capable of detecting and tracking structural changes of various Aβ aggregates. This review summarizes currently available examples of BODIPY dyes that have been used to investigate conformational changes of Aβ peptides, self-assembly processes of Aβ, as well as Aβ interactions with various molecules.
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spelling pubmed-77602072020-12-26 BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes Dzyuba, Sergei V. Biosensors (Basel) Review Amyloid formation plays a major role in a number of neurodegenerative diseases, including Alzheimer’s disease. Amyloid-β peptides (Aβ) are one of the primary markers associated with this pathology. Aβ aggregates exhibit a diverse range of morphologies with distinct pathological activities. Recognition of the Aβ aggregates by using small molecule-based probes and sensors should not only enhance understanding of the underlying mechanisms of amyloid formation, but also facilitate the development of therapeutic strategies to interfere with amyloid neurotoxicity. BODIPY (boron dipyrrin) dyes are among the most versatile small molecule fluorophores. BODIPY scaffolds could be functionalized to tune their photophysical properties to the desired ranges as well as to adapt these dyes to various types of conditions and environments. Thus, BODIPY dyes could be viewed as unique platforms for the design of probes and sensors that are capable of detecting and tracking structural changes of various Aβ aggregates. This review summarizes currently available examples of BODIPY dyes that have been used to investigate conformational changes of Aβ peptides, self-assembly processes of Aβ, as well as Aβ interactions with various molecules. MDPI 2020-11-27 /pmc/articles/PMC7760207/ /pubmed/33260945 http://dx.doi.org/10.3390/bios10120192 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dzyuba, Sergei V.
BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes
title BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes
title_full BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes
title_fullStr BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes
title_full_unstemmed BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes
title_short BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes
title_sort bodipy dyes as probes and sensors to study amyloid-β-related processes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760207/
https://www.ncbi.nlm.nih.gov/pubmed/33260945
http://dx.doi.org/10.3390/bios10120192
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