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BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes
Amyloid formation plays a major role in a number of neurodegenerative diseases, including Alzheimer’s disease. Amyloid-β peptides (Aβ) are one of the primary markers associated with this pathology. Aβ aggregates exhibit a diverse range of morphologies with distinct pathological activities. Recogniti...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760207/ https://www.ncbi.nlm.nih.gov/pubmed/33260945 http://dx.doi.org/10.3390/bios10120192 |
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author | Dzyuba, Sergei V. |
author_facet | Dzyuba, Sergei V. |
author_sort | Dzyuba, Sergei V. |
collection | PubMed |
description | Amyloid formation plays a major role in a number of neurodegenerative diseases, including Alzheimer’s disease. Amyloid-β peptides (Aβ) are one of the primary markers associated with this pathology. Aβ aggregates exhibit a diverse range of morphologies with distinct pathological activities. Recognition of the Aβ aggregates by using small molecule-based probes and sensors should not only enhance understanding of the underlying mechanisms of amyloid formation, but also facilitate the development of therapeutic strategies to interfere with amyloid neurotoxicity. BODIPY (boron dipyrrin) dyes are among the most versatile small molecule fluorophores. BODIPY scaffolds could be functionalized to tune their photophysical properties to the desired ranges as well as to adapt these dyes to various types of conditions and environments. Thus, BODIPY dyes could be viewed as unique platforms for the design of probes and sensors that are capable of detecting and tracking structural changes of various Aβ aggregates. This review summarizes currently available examples of BODIPY dyes that have been used to investigate conformational changes of Aβ peptides, self-assembly processes of Aβ, as well as Aβ interactions with various molecules. |
format | Online Article Text |
id | pubmed-7760207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77602072020-12-26 BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes Dzyuba, Sergei V. Biosensors (Basel) Review Amyloid formation plays a major role in a number of neurodegenerative diseases, including Alzheimer’s disease. Amyloid-β peptides (Aβ) are one of the primary markers associated with this pathology. Aβ aggregates exhibit a diverse range of morphologies with distinct pathological activities. Recognition of the Aβ aggregates by using small molecule-based probes and sensors should not only enhance understanding of the underlying mechanisms of amyloid formation, but also facilitate the development of therapeutic strategies to interfere with amyloid neurotoxicity. BODIPY (boron dipyrrin) dyes are among the most versatile small molecule fluorophores. BODIPY scaffolds could be functionalized to tune their photophysical properties to the desired ranges as well as to adapt these dyes to various types of conditions and environments. Thus, BODIPY dyes could be viewed as unique platforms for the design of probes and sensors that are capable of detecting and tracking structural changes of various Aβ aggregates. This review summarizes currently available examples of BODIPY dyes that have been used to investigate conformational changes of Aβ peptides, self-assembly processes of Aβ, as well as Aβ interactions with various molecules. MDPI 2020-11-27 /pmc/articles/PMC7760207/ /pubmed/33260945 http://dx.doi.org/10.3390/bios10120192 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dzyuba, Sergei V. BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes |
title | BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes |
title_full | BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes |
title_fullStr | BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes |
title_full_unstemmed | BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes |
title_short | BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes |
title_sort | bodipy dyes as probes and sensors to study amyloid-β-related processes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760207/ https://www.ncbi.nlm.nih.gov/pubmed/33260945 http://dx.doi.org/10.3390/bios10120192 |
work_keys_str_mv | AT dzyubasergeiv bodipydyesasprobesandsensorstostudyamyloidbrelatedprocesses |