Cargando…

The 25 kDa H(CN) Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity

The extraordinarily potent clostridial neurotoxins (CNTs) comprise tetanus neurotoxin (TeNT) and the seven established botulinum neurotoxin serotypes (BoNT/A-G). They are composed of four structurally independent domains: the roles of the catalytically active light chain, the translocation domain H(...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deppe, Julian, Weisemann, Jasmin, Mahrhold, Stefan, Rummel, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760224/ https://www.ncbi.nlm.nih.gov/pubmed/33255952 http://dx.doi.org/10.3390/toxins12120743

Ejemplares similares

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin
por: Weisemann, Jasmin, et al.
Publicado: (2016)

Clostridial Neurotoxins: Mechanism of SNARE Cleavage and Outlook on Potential Substrate Specificity Reengineering
por: Binz, Thomas, et al.
Publicado: (2010)

Advances in Clostridial and Related Neurotoxins
por: Pellett, Sabine
Publicado: (2022)

Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H
por: Yao, Guorui, et al.
Publicado: (2017)

Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A–F Employing Taguchi Design-of-Experiments
por: von Berg, Laura, et al.
Publicado: (2019)

Data on physicochemical properties of LPEI 25 kDa, PEI“Max” 40 kDa and PEIpro™
por: Delafosse, Laurence, et al.
Publicado: (2016)

Identification and Characterization of a 25 kDa Protein That Is Indispensable for the Efficient Saccharification of Eisenia bicyclis in the Digestive Fluid of Aplysia kurodai
por: Tsuji, Akihiko, et al.
Publicado: (2017)

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency
por: Stern, Daniel, et al.
Publicado: (2018)

Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology
por: von Berg, Laura, et al.
Publicado: (2019)

Enhanced gene transfection efficiency by low-dose 25 kDa polyethylenimine by the assistance of 1.8 kDa polyethylenimine
por: Zhang, Hui, et al.
Publicado: (2018)

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding
por: Yao, Guorui, et al.
Publicado: (2017)

The Aggregation and Neurotoxicity of TDP-43 and Its ALS-Associated 25 kDa Fragment Are Differentially Affected by Molecular Chaperones in Drosophila
por: Gregory, Jenna M., et al.
Publicado: (2012)

Retargeted Clostridial Neurotoxins as Novel Agents for Treating Chronic Diseases
por: Yeh, Felix L., et al.
Publicado: (2011)

Resolving the Molecular Steps in Clostridial Neurotoxin Light Chain Translocation
por: Zuverink, Madison, et al.
Publicado: (2020)

Clostridial Neurotoxins: Structure, Function and Implications to Other Bacterial Toxins
por: Cai, Shuowei, et al.
Publicado: (2021)

Cloning and promoter analysis of palladin 90-kDa, 140-kDa, and 200-kDa isoforms involved in skeletal muscle cell maturation
por: Ouali, Boimpoundi Eunice Flavie, et al.
Publicado: (2020)

Insights into the evolutionary origins of clostridial neurotoxins from analysis of the Clostridium botulinum strain A neurotoxin gene cluster
por: Doxey, Andrew C, et al.
Publicado: (2008)

Botulinum neurotoxin–encoding plasmids can be conjugatively transferred to diverse clostridial strains
por: Nawrocki, Erin M., et al.
Publicado: (2018)

In Vitro Inhibition of Angiogenesis by Antibodies Directed against the 37kDa/67kDa Laminin Receptor
por: Khusal, Raksha, et al.
Publicado: (2013)

Expression of the 60 kDa and 71 kDa heat shock proteins and presence of antibodies against the 71 kDa heat shock protein in pediatric patients with immune thrombocytopenic purpura
por: Xiao, Chengfeng, et al.
Publicado: (2004)

Crystal structure of the 25 kDa subunit of human cleavage factor I(m)
por: Coseno, Molly, et al.
Publicado: (2008)

A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1
por: Lam, Kwok-ho, et al.
Publicado: (2018)

The 37kDa/67kDa Laminin Receptor acts as a receptor for Aβ(42) internalization
por: Da Costa Dias, Bianca, et al.
Publicado: (2014)

Knock-Down of the 37kDa/67kDa Laminin Receptor LRP/LR Impedes Telomerase Activity
por: Naidoo, Kerrilyn, et al.
Publicado: (2015)

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q(58)–K(59) Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities
por: Sikorra, Stefan, et al.
Publicado: (2018)

Synaptosomal Protein of 25 kDa (Snap25) Polymorphisms Associated with Glycemic Parameters in Type 2 Diabetes Patients
por: Al-Daghri, Nasser M., et al.
Publicado: (2016)

The 18 kDa Translocator Protein, Microglia and Neuroinflammation
por: Liu, Guo‐Jun, et al.
Publicado: (2014)

Monodisperse 130 kDa and 260 kDa Recombinant Human Hemoglobin Polymers as Scaffolds for Protein Engineering of Hemoglobin-Based Oxygen Carriers
por: Marquardt, David A., et al.
Publicado: (2012)

The Novel Clostridial Neurotoxin Produced by Strain IBCA10-7060 Is Immunologically Equivalent to BoNT/HA
por: Fan, Yongfeng, et al.
Publicado: (2019)

Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins
por: Cao, Yanlu, et al.
Publicado: (2021)

MALDI-TOF High Mass Calibration up to 200 kDa Using Human Recombinant 16 kDa Protein Histidine Phosphatase Aggregates
por: Ludwig, Katrin, et al.
Publicado: (2011)

Neurotoxic 43-kDa TAR DNA-binding Protein (TDP-43) Triggers Mitochondrion-dependent Programmed Cell Death in Yeast
por: Braun, Ralf J., et al.
Publicado: (2011)

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A
por: Yao, Guorui, et al.
Publicado: (2016)

Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype
por: Kull, Skadi, et al.
Publicado: (2015)

Antimicrobial Properties of an Immunomodulator - 15 kDa Human Granulysin
por: Wei, Hung-Mu, et al.
Publicado: (2016)

Structural Analysis of the 42 kDa Parvulin of Trypanosoma brucei
por: Rehic, Edisa, et al.
Publicado: (2019)

The Role of Heat Shock Protein 70 kDa in Asthma
por: Shevchenko, Marina, et al.
Publicado: (2021)

Life-Threatening Clostridial Sepsis in a Postmenopausal Patient with Degenerating Uterine Leiomyoma
por: Bryant, Christopher S., et al.
Publicado: (2010)

High Resolution Imaging Study of Interactions between the 37 kDa/67 kDa Laminin Receptor and APP, Beta-Secretase and Gamma-Secretase in Alzheimer's Disease
por: Jovanovic, Katarina, et al.
Publicado: (2014)

Identification of the Interactors of Human Nibrin (NBN) and of Its 26 kDa and 70 kDa Fragments Arising from the NBN 657del5 Founder Mutation
por: Cilli, Domenica, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_tr9gg8js21h76cht132ngb5hdd