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Epidemiology of Hypoalbuminemia in Hospitalized Patients: A Clinical Matter or an Emerging Public Health Problem?

Serum albumin levels are strongly associated with the morbidity, prognosis, and mortality rates of patients with hypoalbuminemia, which is a frequent problem during hospitalization. An observational retrospective study was carried out to analyze changes in albumin levels in hospitalized patients at...

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Autores principales: Moramarco, Stefania, Morciano, Laura, Morucci, Luca, Messinese, Mario, Gualtieri, Paola, Carestia, Mariachiara, Ciccacci, Fausto, Orlando, Stefano, Buonomo, Ersilia, Legramante, Jacopo Maria, De Lorenzo, Antonino, Palombi, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760225/
https://www.ncbi.nlm.nih.gov/pubmed/33261019
http://dx.doi.org/10.3390/nu12123656
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author Moramarco, Stefania
Morciano, Laura
Morucci, Luca
Messinese, Mario
Gualtieri, Paola
Carestia, Mariachiara
Ciccacci, Fausto
Orlando, Stefano
Buonomo, Ersilia
Legramante, Jacopo Maria
De Lorenzo, Antonino
Palombi, Leonardo
author_facet Moramarco, Stefania
Morciano, Laura
Morucci, Luca
Messinese, Mario
Gualtieri, Paola
Carestia, Mariachiara
Ciccacci, Fausto
Orlando, Stefano
Buonomo, Ersilia
Legramante, Jacopo Maria
De Lorenzo, Antonino
Palombi, Leonardo
author_sort Moramarco, Stefania
collection PubMed
description Serum albumin levels are strongly associated with the morbidity, prognosis, and mortality rates of patients with hypoalbuminemia, which is a frequent problem during hospitalization. An observational retrospective study was carried out to analyze changes in albumin levels in hospitalized patients at the “Fondazione Policlinico Tor Vergata—PTV” in 2018. The prevalence of preexisting hypoalbuminemia at the time of discharge from hospital was investigated using a sample of 9428 patients. Information was collected from the discharge files recorded in the central informatics system of the hospital. Analysis of albumin levels at admission and at discharge was conducted by classes of albuminemia and then stratified by age. At the time of admission, hypoalbuminemia was found to be present in more than half of the sample, with no sex differences. The serum albumin level tended to decrease with age, with pathologic levels appearing from 50 years and progressive worsening thereafter. The condition of marked and mild hypoalbuminemia was more prevalent in patients over 65 years of age. Our findings suggest that hypoalbuminemia should be considered a dangerous condition in itself and a serious public health problem. We aimed to emphasize the role of albumin as useful marker of the in-hospital malnutrition and frailty, to be integrated in the routinely assessment of patients for reconsidering ad hoc healthcare pathways after discharge from hospital, especially when dealing with fragile populations.
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spelling pubmed-77602252020-12-26 Epidemiology of Hypoalbuminemia in Hospitalized Patients: A Clinical Matter or an Emerging Public Health Problem? Moramarco, Stefania Morciano, Laura Morucci, Luca Messinese, Mario Gualtieri, Paola Carestia, Mariachiara Ciccacci, Fausto Orlando, Stefano Buonomo, Ersilia Legramante, Jacopo Maria De Lorenzo, Antonino Palombi, Leonardo Nutrients Article Serum albumin levels are strongly associated with the morbidity, prognosis, and mortality rates of patients with hypoalbuminemia, which is a frequent problem during hospitalization. An observational retrospective study was carried out to analyze changes in albumin levels in hospitalized patients at the “Fondazione Policlinico Tor Vergata—PTV” in 2018. The prevalence of preexisting hypoalbuminemia at the time of discharge from hospital was investigated using a sample of 9428 patients. Information was collected from the discharge files recorded in the central informatics system of the hospital. Analysis of albumin levels at admission and at discharge was conducted by classes of albuminemia and then stratified by age. At the time of admission, hypoalbuminemia was found to be present in more than half of the sample, with no sex differences. The serum albumin level tended to decrease with age, with pathologic levels appearing from 50 years and progressive worsening thereafter. The condition of marked and mild hypoalbuminemia was more prevalent in patients over 65 years of age. Our findings suggest that hypoalbuminemia should be considered a dangerous condition in itself and a serious public health problem. We aimed to emphasize the role of albumin as useful marker of the in-hospital malnutrition and frailty, to be integrated in the routinely assessment of patients for reconsidering ad hoc healthcare pathways after discharge from hospital, especially when dealing with fragile populations. MDPI 2020-11-27 /pmc/articles/PMC7760225/ /pubmed/33261019 http://dx.doi.org/10.3390/nu12123656 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moramarco, Stefania
Morciano, Laura
Morucci, Luca
Messinese, Mario
Gualtieri, Paola
Carestia, Mariachiara
Ciccacci, Fausto
Orlando, Stefano
Buonomo, Ersilia
Legramante, Jacopo Maria
De Lorenzo, Antonino
Palombi, Leonardo
Epidemiology of Hypoalbuminemia in Hospitalized Patients: A Clinical Matter or an Emerging Public Health Problem?
title Epidemiology of Hypoalbuminemia in Hospitalized Patients: A Clinical Matter or an Emerging Public Health Problem?
title_full Epidemiology of Hypoalbuminemia in Hospitalized Patients: A Clinical Matter or an Emerging Public Health Problem?
title_fullStr Epidemiology of Hypoalbuminemia in Hospitalized Patients: A Clinical Matter or an Emerging Public Health Problem?
title_full_unstemmed Epidemiology of Hypoalbuminemia in Hospitalized Patients: A Clinical Matter or an Emerging Public Health Problem?
title_short Epidemiology of Hypoalbuminemia in Hospitalized Patients: A Clinical Matter or an Emerging Public Health Problem?
title_sort epidemiology of hypoalbuminemia in hospitalized patients: a clinical matter or an emerging public health problem?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760225/
https://www.ncbi.nlm.nih.gov/pubmed/33261019
http://dx.doi.org/10.3390/nu12123656
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