The Genetic Complexity of Prostate Cancer

Prostate cancer (PCa) is a major concern in public health, with many genetically distinct subsets. Genomic alterations in PCa are extraordinarily complex, and both germline and somatic mutations are of great importance in the development of this tumor. The aim of this review is to provide an overvie...

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Autores principales: Compérat, Eva, Wasinger, Gabriel, Oszwald, André, Kain, Renate, Cancel-Tassin, Geraldine, Cussenot, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760266/
https://www.ncbi.nlm.nih.gov/pubmed/33255593
http://dx.doi.org/10.3390/genes11121396
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author Compérat, Eva
Wasinger, Gabriel
Oszwald, André
Kain, Renate
Cancel-Tassin, Geraldine
Cussenot, Olivier
author_facet Compérat, Eva
Wasinger, Gabriel
Oszwald, André
Kain, Renate
Cancel-Tassin, Geraldine
Cussenot, Olivier
author_sort Compérat, Eva
collection PubMed
description Prostate cancer (PCa) is a major concern in public health, with many genetically distinct subsets. Genomic alterations in PCa are extraordinarily complex, and both germline and somatic mutations are of great importance in the development of this tumor. The aim of this review is to provide an overview of genetic changes that can occur in the development of PCa and their role in potential therapeutic approaches. Various pathways and mechanisms proposed to play major roles in PCa are described in detail to provide an overview of current knowledge.
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spelling pubmed-77602662020-12-26 The Genetic Complexity of Prostate Cancer Compérat, Eva Wasinger, Gabriel Oszwald, André Kain, Renate Cancel-Tassin, Geraldine Cussenot, Olivier Genes (Basel) Review Prostate cancer (PCa) is a major concern in public health, with many genetically distinct subsets. Genomic alterations in PCa are extraordinarily complex, and both germline and somatic mutations are of great importance in the development of this tumor. The aim of this review is to provide an overview of genetic changes that can occur in the development of PCa and their role in potential therapeutic approaches. Various pathways and mechanisms proposed to play major roles in PCa are described in detail to provide an overview of current knowledge. MDPI 2020-11-25 /pmc/articles/PMC7760266/ /pubmed/33255593 http://dx.doi.org/10.3390/genes11121396 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Compérat, Eva
Wasinger, Gabriel
Oszwald, André
Kain, Renate
Cancel-Tassin, Geraldine
Cussenot, Olivier
The Genetic Complexity of Prostate Cancer
title The Genetic Complexity of Prostate Cancer
title_full The Genetic Complexity of Prostate Cancer
title_fullStr The Genetic Complexity of Prostate Cancer
title_full_unstemmed The Genetic Complexity of Prostate Cancer
title_short The Genetic Complexity of Prostate Cancer
title_sort genetic complexity of prostate cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760266/
https://www.ncbi.nlm.nih.gov/pubmed/33255593
http://dx.doi.org/10.3390/genes11121396
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