Cargando…

Numerical Investigation on the Role of Mechanical Factors Contributing to Globe Flattening in States of Elevated Intracranial Pressure

Flattening of the posterior eye globe in the magnetic resonance (MR) images is a sign associated with elevated intracranial pressure (ICP), often seen in people with idiopathic intracranial hypertension (IIH). The exact underlying mechanisms of globe flattening (GF) are not fully known but mechanica...

Descripción completa

Detalles Bibliográficos
Autores principales: Mehr, Jafar A., Moss, Heather E., Hatami-Marbini, Hamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760332/
https://www.ncbi.nlm.nih.gov/pubmed/33260780
http://dx.doi.org/10.3390/life10120316
_version_ 1783627307833884672
author Mehr, Jafar A.
Moss, Heather E.
Hatami-Marbini, Hamed
author_facet Mehr, Jafar A.
Moss, Heather E.
Hatami-Marbini, Hamed
author_sort Mehr, Jafar A.
collection PubMed
description Flattening of the posterior eye globe in the magnetic resonance (MR) images is a sign associated with elevated intracranial pressure (ICP), often seen in people with idiopathic intracranial hypertension (IIH). The exact underlying mechanisms of globe flattening (GF) are not fully known but mechanical factors are believed to play a role. In the present study, we investigated the effects of material properties and pressure loads on GF. For this purpose, we used a generic finite element model to investigate the deformation of the posterior eyeball. The degree of GF in numerical models and the significance of different mechanical factors on GF were characterized using an automated angle-slope technique and a statistical measure. From the numerical models, we found that ICP had the most important role in GF. We also showed that the angle-slope graphs pertaining to MR images from five people with high ICP can be represented numerically by manipulating the parameters of the finite element model. This numerical study suggests that GF observed in IIH patients can be accounted for by the forces caused by elevation of ICP from its normal level, while material properties of ocular tissues, such as sclera (SC), peripapillary sclera (PSC), and optic nerve (ON), would impact its severity.
format Online
Article
Text
id pubmed-7760332
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77603322020-12-26 Numerical Investigation on the Role of Mechanical Factors Contributing to Globe Flattening in States of Elevated Intracranial Pressure Mehr, Jafar A. Moss, Heather E. Hatami-Marbini, Hamed Life (Basel) Article Flattening of the posterior eye globe in the magnetic resonance (MR) images is a sign associated with elevated intracranial pressure (ICP), often seen in people with idiopathic intracranial hypertension (IIH). The exact underlying mechanisms of globe flattening (GF) are not fully known but mechanical factors are believed to play a role. In the present study, we investigated the effects of material properties and pressure loads on GF. For this purpose, we used a generic finite element model to investigate the deformation of the posterior eyeball. The degree of GF in numerical models and the significance of different mechanical factors on GF were characterized using an automated angle-slope technique and a statistical measure. From the numerical models, we found that ICP had the most important role in GF. We also showed that the angle-slope graphs pertaining to MR images from five people with high ICP can be represented numerically by manipulating the parameters of the finite element model. This numerical study suggests that GF observed in IIH patients can be accounted for by the forces caused by elevation of ICP from its normal level, while material properties of ocular tissues, such as sclera (SC), peripapillary sclera (PSC), and optic nerve (ON), would impact its severity. MDPI 2020-11-28 /pmc/articles/PMC7760332/ /pubmed/33260780 http://dx.doi.org/10.3390/life10120316 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mehr, Jafar A.
Moss, Heather E.
Hatami-Marbini, Hamed
Numerical Investigation on the Role of Mechanical Factors Contributing to Globe Flattening in States of Elevated Intracranial Pressure
title Numerical Investigation on the Role of Mechanical Factors Contributing to Globe Flattening in States of Elevated Intracranial Pressure
title_full Numerical Investigation on the Role of Mechanical Factors Contributing to Globe Flattening in States of Elevated Intracranial Pressure
title_fullStr Numerical Investigation on the Role of Mechanical Factors Contributing to Globe Flattening in States of Elevated Intracranial Pressure
title_full_unstemmed Numerical Investigation on the Role of Mechanical Factors Contributing to Globe Flattening in States of Elevated Intracranial Pressure
title_short Numerical Investigation on the Role of Mechanical Factors Contributing to Globe Flattening in States of Elevated Intracranial Pressure
title_sort numerical investigation on the role of mechanical factors contributing to globe flattening in states of elevated intracranial pressure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760332/
https://www.ncbi.nlm.nih.gov/pubmed/33260780
http://dx.doi.org/10.3390/life10120316
work_keys_str_mv AT mehrjafara numericalinvestigationontheroleofmechanicalfactorscontributingtoglobeflatteninginstatesofelevatedintracranialpressure
AT mossheathere numericalinvestigationontheroleofmechanicalfactorscontributingtoglobeflatteninginstatesofelevatedintracranialpressure
AT hatamimarbinihamed numericalinvestigationontheroleofmechanicalfactorscontributingtoglobeflatteninginstatesofelevatedintracranialpressure