Cargando…
Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records
Early intervention of gestational diabetes mellitus (GDM) is effective in reducing pregnancy disorders. Fetal growth, measured by routine ultrasound scan a few weeks earlier before GDM diagnosis, might be useful to identify women at high risk of GDM. In the study, generalized estimating equations we...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760346/ https://www.ncbi.nlm.nih.gov/pubmed/33260833 http://dx.doi.org/10.3390/nu12123645 |
_version_ | 1783627311213445120 |
---|---|
author | Jin, Danyao Rich-Edwards, Janet Wilson Chen, Chunyi Huang, Yue Wang, Yinping Xu, Xiangrong Liu, Jue Liu, Zheng Gao, Yaqing Zou, Siyu Zhou, Hong Wang, Haijun |
author_facet | Jin, Danyao Rich-Edwards, Janet Wilson Chen, Chunyi Huang, Yue Wang, Yinping Xu, Xiangrong Liu, Jue Liu, Zheng Gao, Yaqing Zou, Siyu Zhou, Hong Wang, Haijun |
author_sort | Jin, Danyao |
collection | PubMed |
description | Early intervention of gestational diabetes mellitus (GDM) is effective in reducing pregnancy disorders. Fetal growth, measured by routine ultrasound scan a few weeks earlier before GDM diagnosis, might be useful to identify women at high risk of GDM. In the study, generalized estimating equations were applied to examine the associations between ultrasonic indicators of abnormal fetal growth at 22–24 weeks and the risk of subsequent GDM diagnosis. Of 44,179 deliveries, 8324 (18.8%) were diagnosed with GDM between 24 and 28 weeks. At 22–24 weeks, fetal head circumference (HC) < 10th, fetal femur length (FL) < 10th, and estimated fetal weight (EFW) < 10th percentile were associated with 13% to 17% increased risks of maternal GDM diagnosis. Small fetal size appeared to be especially predictive of GDM among women who were parous. Fetal growth in the highest decile of abdominal circumference (AC), HC, FL and EFW was not associated with risk of subsequent GDM. The observed mean difference in fetal size across gestation by GDM was small; there was less than 1 mm difference for AC, HC, and FL, and less than 5 g for EFW before 24 weeks. Despite similar mean fetal growth among women who were and were not later diagnosed with GDM, mothers with fetuses in the lowest decile of HC, FL and EFW at 22–24 weeks tended to have higher risk of GDM. |
format | Online Article Text |
id | pubmed-7760346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77603462020-12-26 Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records Jin, Danyao Rich-Edwards, Janet Wilson Chen, Chunyi Huang, Yue Wang, Yinping Xu, Xiangrong Liu, Jue Liu, Zheng Gao, Yaqing Zou, Siyu Zhou, Hong Wang, Haijun Nutrients Article Early intervention of gestational diabetes mellitus (GDM) is effective in reducing pregnancy disorders. Fetal growth, measured by routine ultrasound scan a few weeks earlier before GDM diagnosis, might be useful to identify women at high risk of GDM. In the study, generalized estimating equations were applied to examine the associations between ultrasonic indicators of abnormal fetal growth at 22–24 weeks and the risk of subsequent GDM diagnosis. Of 44,179 deliveries, 8324 (18.8%) were diagnosed with GDM between 24 and 28 weeks. At 22–24 weeks, fetal head circumference (HC) < 10th, fetal femur length (FL) < 10th, and estimated fetal weight (EFW) < 10th percentile were associated with 13% to 17% increased risks of maternal GDM diagnosis. Small fetal size appeared to be especially predictive of GDM among women who were parous. Fetal growth in the highest decile of abdominal circumference (AC), HC, FL and EFW was not associated with risk of subsequent GDM. The observed mean difference in fetal size across gestation by GDM was small; there was less than 1 mm difference for AC, HC, and FL, and less than 5 g for EFW before 24 weeks. Despite similar mean fetal growth among women who were and were not later diagnosed with GDM, mothers with fetuses in the lowest decile of HC, FL and EFW at 22–24 weeks tended to have higher risk of GDM. MDPI 2020-11-27 /pmc/articles/PMC7760346/ /pubmed/33260833 http://dx.doi.org/10.3390/nu12123645 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jin, Danyao Rich-Edwards, Janet Wilson Chen, Chunyi Huang, Yue Wang, Yinping Xu, Xiangrong Liu, Jue Liu, Zheng Gao, Yaqing Zou, Siyu Zhou, Hong Wang, Haijun Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records |
title | Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records |
title_full | Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records |
title_fullStr | Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records |
title_full_unstemmed | Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records |
title_short | Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records |
title_sort | gestational diabetes mellitus: predictive value of fetal growth measurements by ultrasonography at 22–24 weeks: a retrospective cohort study of medical records |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760346/ https://www.ncbi.nlm.nih.gov/pubmed/33260833 http://dx.doi.org/10.3390/nu12123645 |
work_keys_str_mv | AT jindanyao gestationaldiabetesmellituspredictivevalueoffetalgrowthmeasurementsbyultrasonographyat2224weeksaretrospectivecohortstudyofmedicalrecords AT richedwardsjanetwilson gestationaldiabetesmellituspredictivevalueoffetalgrowthmeasurementsbyultrasonographyat2224weeksaretrospectivecohortstudyofmedicalrecords AT chenchunyi gestationaldiabetesmellituspredictivevalueoffetalgrowthmeasurementsbyultrasonographyat2224weeksaretrospectivecohortstudyofmedicalrecords AT huangyue gestationaldiabetesmellituspredictivevalueoffetalgrowthmeasurementsbyultrasonographyat2224weeksaretrospectivecohortstudyofmedicalrecords AT wangyinping gestationaldiabetesmellituspredictivevalueoffetalgrowthmeasurementsbyultrasonographyat2224weeksaretrospectivecohortstudyofmedicalrecords AT xuxiangrong gestationaldiabetesmellituspredictivevalueoffetalgrowthmeasurementsbyultrasonographyat2224weeksaretrospectivecohortstudyofmedicalrecords AT liujue gestationaldiabetesmellituspredictivevalueoffetalgrowthmeasurementsbyultrasonographyat2224weeksaretrospectivecohortstudyofmedicalrecords AT liuzheng gestationaldiabetesmellituspredictivevalueoffetalgrowthmeasurementsbyultrasonographyat2224weeksaretrospectivecohortstudyofmedicalrecords AT gaoyaqing gestationaldiabetesmellituspredictivevalueoffetalgrowthmeasurementsbyultrasonographyat2224weeksaretrospectivecohortstudyofmedicalrecords AT zousiyu gestationaldiabetesmellituspredictivevalueoffetalgrowthmeasurementsbyultrasonographyat2224weeksaretrospectivecohortstudyofmedicalrecords AT zhouhong gestationaldiabetesmellituspredictivevalueoffetalgrowthmeasurementsbyultrasonographyat2224weeksaretrospectivecohortstudyofmedicalrecords AT wanghaijun gestationaldiabetesmellituspredictivevalueoffetalgrowthmeasurementsbyultrasonographyat2224weeksaretrospectivecohortstudyofmedicalrecords |