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Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records

Early intervention of gestational diabetes mellitus (GDM) is effective in reducing pregnancy disorders. Fetal growth, measured by routine ultrasound scan a few weeks earlier before GDM diagnosis, might be useful to identify women at high risk of GDM. In the study, generalized estimating equations we...

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Autores principales: Jin, Danyao, Rich-Edwards, Janet Wilson, Chen, Chunyi, Huang, Yue, Wang, Yinping, Xu, Xiangrong, Liu, Jue, Liu, Zheng, Gao, Yaqing, Zou, Siyu, Zhou, Hong, Wang, Haijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760346/
https://www.ncbi.nlm.nih.gov/pubmed/33260833
http://dx.doi.org/10.3390/nu12123645
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author Jin, Danyao
Rich-Edwards, Janet Wilson
Chen, Chunyi
Huang, Yue
Wang, Yinping
Xu, Xiangrong
Liu, Jue
Liu, Zheng
Gao, Yaqing
Zou, Siyu
Zhou, Hong
Wang, Haijun
author_facet Jin, Danyao
Rich-Edwards, Janet Wilson
Chen, Chunyi
Huang, Yue
Wang, Yinping
Xu, Xiangrong
Liu, Jue
Liu, Zheng
Gao, Yaqing
Zou, Siyu
Zhou, Hong
Wang, Haijun
author_sort Jin, Danyao
collection PubMed
description Early intervention of gestational diabetes mellitus (GDM) is effective in reducing pregnancy disorders. Fetal growth, measured by routine ultrasound scan a few weeks earlier before GDM diagnosis, might be useful to identify women at high risk of GDM. In the study, generalized estimating equations were applied to examine the associations between ultrasonic indicators of abnormal fetal growth at 22–24 weeks and the risk of subsequent GDM diagnosis. Of 44,179 deliveries, 8324 (18.8%) were diagnosed with GDM between 24 and 28 weeks. At 22–24 weeks, fetal head circumference (HC) < 10th, fetal femur length (FL) < 10th, and estimated fetal weight (EFW) < 10th percentile were associated with 13% to 17% increased risks of maternal GDM diagnosis. Small fetal size appeared to be especially predictive of GDM among women who were parous. Fetal growth in the highest decile of abdominal circumference (AC), HC, FL and EFW was not associated with risk of subsequent GDM. The observed mean difference in fetal size across gestation by GDM was small; there was less than 1 mm difference for AC, HC, and FL, and less than 5 g for EFW before 24 weeks. Despite similar mean fetal growth among women who were and were not later diagnosed with GDM, mothers with fetuses in the lowest decile of HC, FL and EFW at 22–24 weeks tended to have higher risk of GDM.
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spelling pubmed-77603462020-12-26 Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records Jin, Danyao Rich-Edwards, Janet Wilson Chen, Chunyi Huang, Yue Wang, Yinping Xu, Xiangrong Liu, Jue Liu, Zheng Gao, Yaqing Zou, Siyu Zhou, Hong Wang, Haijun Nutrients Article Early intervention of gestational diabetes mellitus (GDM) is effective in reducing pregnancy disorders. Fetal growth, measured by routine ultrasound scan a few weeks earlier before GDM diagnosis, might be useful to identify women at high risk of GDM. In the study, generalized estimating equations were applied to examine the associations between ultrasonic indicators of abnormal fetal growth at 22–24 weeks and the risk of subsequent GDM diagnosis. Of 44,179 deliveries, 8324 (18.8%) were diagnosed with GDM between 24 and 28 weeks. At 22–24 weeks, fetal head circumference (HC) < 10th, fetal femur length (FL) < 10th, and estimated fetal weight (EFW) < 10th percentile were associated with 13% to 17% increased risks of maternal GDM diagnosis. Small fetal size appeared to be especially predictive of GDM among women who were parous. Fetal growth in the highest decile of abdominal circumference (AC), HC, FL and EFW was not associated with risk of subsequent GDM. The observed mean difference in fetal size across gestation by GDM was small; there was less than 1 mm difference for AC, HC, and FL, and less than 5 g for EFW before 24 weeks. Despite similar mean fetal growth among women who were and were not later diagnosed with GDM, mothers with fetuses in the lowest decile of HC, FL and EFW at 22–24 weeks tended to have higher risk of GDM. MDPI 2020-11-27 /pmc/articles/PMC7760346/ /pubmed/33260833 http://dx.doi.org/10.3390/nu12123645 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jin, Danyao
Rich-Edwards, Janet Wilson
Chen, Chunyi
Huang, Yue
Wang, Yinping
Xu, Xiangrong
Liu, Jue
Liu, Zheng
Gao, Yaqing
Zou, Siyu
Zhou, Hong
Wang, Haijun
Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records
title Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records
title_full Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records
title_fullStr Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records
title_full_unstemmed Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records
title_short Gestational Diabetes Mellitus: Predictive Value of Fetal Growth Measurements by Ultrasonography at 22–24 Weeks: A Retrospective Cohort Study of Medical Records
title_sort gestational diabetes mellitus: predictive value of fetal growth measurements by ultrasonography at 22–24 weeks: a retrospective cohort study of medical records
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760346/
https://www.ncbi.nlm.nih.gov/pubmed/33260833
http://dx.doi.org/10.3390/nu12123645
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