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Factors Associated with the Prescribing of High-Intensity Statins

In this study, we investigated the relationship between sociodemographic, clinical, anthropometric, and lifestyle characteristics and the type of statin prescribed for primary prevention of cardiovascular disease (CVD). We conducted an observational study in workers who began statin treatment. Stati...

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Autores principales: Chaure-Pardos, Armando, Malo, Sara, Rabanaque, María José, Arribas, Federico, Moreno-Franco, Belén, Aguilar-Palacio, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760403/
https://www.ncbi.nlm.nih.gov/pubmed/33260835
http://dx.doi.org/10.3390/jcm9123850
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author Chaure-Pardos, Armando
Malo, Sara
Rabanaque, María José
Arribas, Federico
Moreno-Franco, Belén
Aguilar-Palacio, Isabel
author_facet Chaure-Pardos, Armando
Malo, Sara
Rabanaque, María José
Arribas, Federico
Moreno-Franco, Belén
Aguilar-Palacio, Isabel
author_sort Chaure-Pardos, Armando
collection PubMed
description In this study, we investigated the relationship between sociodemographic, clinical, anthropometric, and lifestyle characteristics and the type of statin prescribed for primary prevention of cardiovascular disease (CVD). We conducted an observational study in workers who began statin treatment. Statin therapy was categorized as “high-intensity” or “low–moderate-intensity”. Workers were classified according to the alignment of their statin therapy with the recommended management practices. Logistic regression models were used to evaluate the association between the different variables studied and the probability of being prescribed high-intensity statins. The only variables associated with a higher probability of being treated with high-intensity statins were increased physical activity (>40 versus <20 METs (metabolic equivalent of task) h/wk; odds ratio (OR), 1.65; 95%CI, 1.08–2.50) and, in diabetics, higher low-density lipoprotein cholesterol (LDL-C) levels (≥155 mg/dL versus <155 mg/dL; OR, 4.96; 95%CI, 1.29–19.10). The model that best predicted treatment intensity included LDL-C, diabetes, hypertension, smoking, and age (area under the Receiver Operating Characteristic curve (AUC), 0.620; 95%CI, 0.574–0.666). The prescribing and type of statin used in primary CVD prevention did not correspond with the indications in current guidelines. The probability of receiving high-intensity statins was higher in diabetics with high LDL-C levels and in more physically active individuals. These findings underscore the great variability and uncertainty in the prescribing of statins.
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spelling pubmed-77604032020-12-26 Factors Associated with the Prescribing of High-Intensity Statins Chaure-Pardos, Armando Malo, Sara Rabanaque, María José Arribas, Federico Moreno-Franco, Belén Aguilar-Palacio, Isabel J Clin Med Article In this study, we investigated the relationship between sociodemographic, clinical, anthropometric, and lifestyle characteristics and the type of statin prescribed for primary prevention of cardiovascular disease (CVD). We conducted an observational study in workers who began statin treatment. Statin therapy was categorized as “high-intensity” or “low–moderate-intensity”. Workers were classified according to the alignment of their statin therapy with the recommended management practices. Logistic regression models were used to evaluate the association between the different variables studied and the probability of being prescribed high-intensity statins. The only variables associated with a higher probability of being treated with high-intensity statins were increased physical activity (>40 versus <20 METs (metabolic equivalent of task) h/wk; odds ratio (OR), 1.65; 95%CI, 1.08–2.50) and, in diabetics, higher low-density lipoprotein cholesterol (LDL-C) levels (≥155 mg/dL versus <155 mg/dL; OR, 4.96; 95%CI, 1.29–19.10). The model that best predicted treatment intensity included LDL-C, diabetes, hypertension, smoking, and age (area under the Receiver Operating Characteristic curve (AUC), 0.620; 95%CI, 0.574–0.666). The prescribing and type of statin used in primary CVD prevention did not correspond with the indications in current guidelines. The probability of receiving high-intensity statins was higher in diabetics with high LDL-C levels and in more physically active individuals. These findings underscore the great variability and uncertainty in the prescribing of statins. MDPI 2020-11-27 /pmc/articles/PMC7760403/ /pubmed/33260835 http://dx.doi.org/10.3390/jcm9123850 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chaure-Pardos, Armando
Malo, Sara
Rabanaque, María José
Arribas, Federico
Moreno-Franco, Belén
Aguilar-Palacio, Isabel
Factors Associated with the Prescribing of High-Intensity Statins
title Factors Associated with the Prescribing of High-Intensity Statins
title_full Factors Associated with the Prescribing of High-Intensity Statins
title_fullStr Factors Associated with the Prescribing of High-Intensity Statins
title_full_unstemmed Factors Associated with the Prescribing of High-Intensity Statins
title_short Factors Associated with the Prescribing of High-Intensity Statins
title_sort factors associated with the prescribing of high-intensity statins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760403/
https://www.ncbi.nlm.nih.gov/pubmed/33260835
http://dx.doi.org/10.3390/jcm9123850
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