Reduced Expression of Cerebral Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome

Glutamatergic receptor expression is mostly unknown in adults with fragile X syndrome (FXS). Favorable behavioral effects of negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGluR(5)) in fmr1 knockout (KO) mouse models have not been confirmed in humans with FXS...

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Detalles Bibliográficos
Autores principales: Brašić, James R., Nandi, Ayon, Russell, David S., Jennings, Danna, Barret, Olivier, Mathur, Anil, Slifer, Keith, Sedlak, Thomas, Martin, Samuel D., Brinson, Zabecca, Vyas, Pankhuri, Seibyl, John P., Berry-Kravis, Elizabeth M., Wong, Dean F., Budimirovic, Dejan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760509/
https://www.ncbi.nlm.nih.gov/pubmed/33255214
http://dx.doi.org/10.3390/brainsci10120899

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