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MRI Characteristics Accurately Predict Biochemical Recurrence after Radical Prostatectomy

Background: After radical prostatectomy (RP), biochemical recurrence (BCR) is associated with an increased risk of developing distant metastasis and prostate cancer specific and overall mortality. Methods: The two-centre study included 521 consecutive patients undergoing RP for positive pre-biopsy m...

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Autores principales: Manceau, Cécile, Beauval, Jean-Baptiste, Lesourd, Marine, Almeras, Christophe, Aziza, Richard, Gautier, Jean-Romain, Loison, Guillaume, Salin, Ambroise, Tollon, Christophe, Soulié, Michel, Malavaud, Bernard, Roumiguié, Mathieu, Ploussard, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760513/
https://www.ncbi.nlm.nih.gov/pubmed/33256176
http://dx.doi.org/10.3390/jcm9123841
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author Manceau, Cécile
Beauval, Jean-Baptiste
Lesourd, Marine
Almeras, Christophe
Aziza, Richard
Gautier, Jean-Romain
Loison, Guillaume
Salin, Ambroise
Tollon, Christophe
Soulié, Michel
Malavaud, Bernard
Roumiguié, Mathieu
Ploussard, Guillaume
author_facet Manceau, Cécile
Beauval, Jean-Baptiste
Lesourd, Marine
Almeras, Christophe
Aziza, Richard
Gautier, Jean-Romain
Loison, Guillaume
Salin, Ambroise
Tollon, Christophe
Soulié, Michel
Malavaud, Bernard
Roumiguié, Mathieu
Ploussard, Guillaume
author_sort Manceau, Cécile
collection PubMed
description Background: After radical prostatectomy (RP), biochemical recurrence (BCR) is associated with an increased risk of developing distant metastasis and prostate cancer specific and overall mortality. Methods: The two-centre study included 521 consecutive patients undergoing RP for positive pre-biopsy magnetic resonance imaging (MRI) and pathologically proven prostate cancer (PCa), after which a combination scheme of fusion-targeted biopsy (TB) and systematic biopsy was performed. We assessed correlations between MRI characteristics, International Society of Urological Pathology (ISUP) grade group in TB, and outcomes after RP. We developed an imaging-based risk classification for improving BCR prediction. Results: Higher Prostate Imaging and Reporting and Data System (PI-RADS) score (p = 0.013), higher ISUP grade group in TB, and extracapsular extension (ECE) on the MRI were significantly associated with more advanced disease (pTstage), higher ISUP grade group (p = 0.001), regional lymph nodes metastasis in RP specimens (p < 0.001), and an increased risk of recurrence after surgery. A positive margin status was significantly associated with ECE-MRI (p < 0.001). Our imaging-based classification included ECE on MRI, ISUP grade group on TB, and PI-RADS accurately predicted BCR (AUC = 0.714, p < 0.001). This classification had more improved area under the curve (AUC) than the standard d’Amico classification in our population. Validation was performed in a two-centre cohort. Conclusions: In this cohort, PI-RADS score, MRI stage, and ISUP grade group in MRI-TB were significantly predictive for disease features and recurrence after RP. Imaging-based risk classification integrating these three factors competed with d’Amico classification for predicting BCR.
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spelling pubmed-77605132020-12-26 MRI Characteristics Accurately Predict Biochemical Recurrence after Radical Prostatectomy Manceau, Cécile Beauval, Jean-Baptiste Lesourd, Marine Almeras, Christophe Aziza, Richard Gautier, Jean-Romain Loison, Guillaume Salin, Ambroise Tollon, Christophe Soulié, Michel Malavaud, Bernard Roumiguié, Mathieu Ploussard, Guillaume J Clin Med Article Background: After radical prostatectomy (RP), biochemical recurrence (BCR) is associated with an increased risk of developing distant metastasis and prostate cancer specific and overall mortality. Methods: The two-centre study included 521 consecutive patients undergoing RP for positive pre-biopsy magnetic resonance imaging (MRI) and pathologically proven prostate cancer (PCa), after which a combination scheme of fusion-targeted biopsy (TB) and systematic biopsy was performed. We assessed correlations between MRI characteristics, International Society of Urological Pathology (ISUP) grade group in TB, and outcomes after RP. We developed an imaging-based risk classification for improving BCR prediction. Results: Higher Prostate Imaging and Reporting and Data System (PI-RADS) score (p = 0.013), higher ISUP grade group in TB, and extracapsular extension (ECE) on the MRI were significantly associated with more advanced disease (pTstage), higher ISUP grade group (p = 0.001), regional lymph nodes metastasis in RP specimens (p < 0.001), and an increased risk of recurrence after surgery. A positive margin status was significantly associated with ECE-MRI (p < 0.001). Our imaging-based classification included ECE on MRI, ISUP grade group on TB, and PI-RADS accurately predicted BCR (AUC = 0.714, p < 0.001). This classification had more improved area under the curve (AUC) than the standard d’Amico classification in our population. Validation was performed in a two-centre cohort. Conclusions: In this cohort, PI-RADS score, MRI stage, and ISUP grade group in MRI-TB were significantly predictive for disease features and recurrence after RP. Imaging-based risk classification integrating these three factors competed with d’Amico classification for predicting BCR. MDPI 2020-11-26 /pmc/articles/PMC7760513/ /pubmed/33256176 http://dx.doi.org/10.3390/jcm9123841 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Manceau, Cécile
Beauval, Jean-Baptiste
Lesourd, Marine
Almeras, Christophe
Aziza, Richard
Gautier, Jean-Romain
Loison, Guillaume
Salin, Ambroise
Tollon, Christophe
Soulié, Michel
Malavaud, Bernard
Roumiguié, Mathieu
Ploussard, Guillaume
MRI Characteristics Accurately Predict Biochemical Recurrence after Radical Prostatectomy
title MRI Characteristics Accurately Predict Biochemical Recurrence after Radical Prostatectomy
title_full MRI Characteristics Accurately Predict Biochemical Recurrence after Radical Prostatectomy
title_fullStr MRI Characteristics Accurately Predict Biochemical Recurrence after Radical Prostatectomy
title_full_unstemmed MRI Characteristics Accurately Predict Biochemical Recurrence after Radical Prostatectomy
title_short MRI Characteristics Accurately Predict Biochemical Recurrence after Radical Prostatectomy
title_sort mri characteristics accurately predict biochemical recurrence after radical prostatectomy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760513/
https://www.ncbi.nlm.nih.gov/pubmed/33256176
http://dx.doi.org/10.3390/jcm9123841
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